几内亚Donka国家医院儿科感染艾滋病毒儿童队列中乙型肝炎的患病率及相关因素

Prevalence and factors associated with hepatitis B in a cohort of HIV-infected children in the Pediatric Department at Donka National Hospital, Guinea.

作者信息

Kaba Djiba, Bangoura Mmah Aminata, Sylla Mariame Moustapha, Sako Fodé Bangaly, Diallo Mariama Sadjo, Diallo Issiaga, Kolié Ouo-Ouo Yaramon, Keita Ahmed Sékou, Diané Boh Fanta, Keita Fatimata, Diakité Mamady, Kanté Mamadou Diouldé, Savané Moussa, Sylla Djibril, Kaké Amadou, Diallo Kadiatou, Touré Mafoudia, Cissé Mohamed

机构信息

Université Gamal Abdel Nasser de Conakry, Conakry, Guinée.

Laboratoire de Biologie Moléculaire Nestor Bangoura/Hélène Labrousse, CTA Hôpital National Donka, Conakry, Guinée.

出版信息

Pan Afr Med J. 2019 Dec 6;34:182. doi: 10.11604/pamj.2019.34.182.16275. eCollection 2019.

DOI:10.11604/pamj.2019.34.182.16275

PMID:32153722

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7046108/

Abstract

INTRODUCTION

children pay a heavy price for infection with the hepatitis B virus (HBV). The objective of this work was to determine the prevalence of hepatitis B and describe the associated factors in children at the pediatric department of Donka Hospital.

METHODS

this was a cross-sectional study of a cohort of children in the pediatric department of Donka Hospital. HBsAg was performed by using an immunochromatographic method. The analysis of the data was done with software R. The proportions were compared using the Chi-square test or the Fisher test at the significance level of 5%. A logistic regression model was used to explain the prevalence of hepatitis B.

RESULTS

one hundred and forty-nine children were recruited between February and July 2017. HBsAg was present in 12 children, i.e. 8.16% (95% CI: 4.29-13.82). The average age was 93.32 months (IQR: 6-180). Male children were the most affected (n = 11, P <0.05), with a sex ratio of 1.01. The majority (51.35%) were on AZT + 3TC + NVP pediatric form and 25% were on AZT + 3TC + NVP adult form and 23.65% on TDF + FTC + EFV. In univariate analysis, ALT, HBsAg positivity, and maternal HBV vaccination status were associated with the prevalence of HBsAg (P <0.05).

CONCLUSION

the prevalence of co-infection in children and adults is almost identical in our context. Hence the importance of strengthening preventive measures at all levels, especially the vaccination of children and mothers.

摘要

引言

儿童感染乙型肝炎病毒（HBV）需付出沉重代价。本研究的目的是确定唐卡医院儿科儿童乙型肝炎的患病率，并描述相关因素。

方法

这是一项对唐卡医院儿科一组儿童进行的横断面研究。采用免疫层析法检测乙肝表面抗原（HBsAg）。使用R软件对数据进行分析。在5%的显著性水平下，使用卡方检验或费舍尔检验比较比例。采用逻辑回归模型解释乙型肝炎的患病率。

结果

2017年2月至7月招募了149名儿童。12名儿童HBsAg呈阳性，即8.16%（95%置信区间：4.29 - 13.82）。平均年龄为93.32个月（四分位间距：6 - 180）。男性儿童受影响最大（n = 11，P <0.05），性别比为1.01。大多数（51.35%）使用AZT + 3TC + NVP儿童剂型，25%使用AZT + 3TC + NVP成人剂型，23.65%使用TDF + FTC + EFV。单因素分析中，丙氨酸氨基转移酶（ALT）、HBsAg阳性以及母亲的乙肝疫苗接种状况与HBsAg的患病率相关（P <0.05）。