Telatela Safila P, Matee Mecky I, Munubhi Emmanuel K
Department of Paediatrics and Child Health, Muhimbili University College of Health Sciences, P,O, Box 65001, Dar es Salaam, Tanzania.
BMC Public Health. 2007 Nov 22;7:338. doi: 10.1186/1471-2458-7-338.
With increased availability of antibiotics and antifungal agents hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are becoming a cause for significant concern in HIV infected children. We determined the seroprevalence and risk factors for HBV and HCV among HIV infected children aged 18 months to 17 years, attending the Paediatric HIV Care and Treatment Center (CTC) at Muhimbili National Hospital (MNH) in Dar-es-Salaam, Tanzania.
Investigations included; interviews, physical examination and serology for HBsAg, IgG antibodies to HCV and alanine aminotransferase (ALT) levels. HIV serostatus and CD4 counts were obtained from patient records.
167 HIV infected children, 88(52.7%) males and 79(47.3%) females were enrolled. The overall prevalence of hepatitis co-infection was 15%, with the seroprevalence of HBV and HCV being 1.2% and 13.8%, respectively. Hepatitis virus co-infection was not associated with any of the investigated risk factors and there was no association between HBV and HCV. Elevated ALT was associated with hepatitis viral co-infection but not with ART usage or immune status.
The high seroprevalence (15%) of hepatitis co-infection in HIV infected children attending the Paediatrics HIV CTC at the MNH calls for routine screening of hepatitis viral co-infection and modification in the management of HIV infected children.
随着抗生素和抗真菌药物的可及性增加,乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)感染在感染HIV的儿童中日益引起严重关注。我们确定了坦桑尼亚达累斯萨拉姆穆希姆比利国家医院(MNH)儿科HIV护理与治疗中心(CTC)18个月至17岁感染HIV儿童中HBV和HCV的血清流行率及危险因素。
调查包括访谈、体格检查以及检测HBsAg、抗HCV IgG抗体和丙氨酸转氨酶(ALT)水平的血清学检查。从患者记录中获取HIV血清状态和CD4细胞计数。
纳入了167名感染HIV的儿童,其中88名(52.7%)为男性,79名(47.3%)为女性。肝炎合并感染的总体患病率为15%,HBV和HCV的血清流行率分别为1.2%和13.8%。肝炎病毒合并感染与任何调查的危险因素均无关联,HBV和HCV之间也无关联。ALT升高与肝炎病毒合并感染有关,但与抗逆转录病毒治疗的使用或免疫状态无关。
在MNH儿科HIV CTC就诊的感染HIV儿童中,肝炎合并感染的血清流行率较高(15%),这就需要对肝炎病毒合并感染进行常规筛查,并对感染HIV儿童的管理进行调整。