Suppr超能文献

在坦桑尼亚达累斯萨拉姆市穆希姆比利国家医院的儿科艾滋病毒护理与治疗中心接受治疗的感染人类免疫缺陷病毒的儿童中,乙型和丙型肝炎病毒合并感染的血清流行率。

Seroprevalence of hepatitis B and C viral co-infections among children infected with human immunodeficiency virus attending the paediatric HIV care and treatment center at Muhimbili National Hospital in Dar-es-Salaam, Tanzania.

作者信息

Telatela Safila P, Matee Mecky I, Munubhi Emmanuel K

机构信息

Department of Paediatrics and Child Health, Muhimbili University College of Health Sciences, P,O, Box 65001, Dar es Salaam, Tanzania.

出版信息

BMC Public Health. 2007 Nov 22;7:338. doi: 10.1186/1471-2458-7-338.

Abstract

BACKGROUND

With increased availability of antibiotics and antifungal agents hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are becoming a cause for significant concern in HIV infected children. We determined the seroprevalence and risk factors for HBV and HCV among HIV infected children aged 18 months to 17 years, attending the Paediatric HIV Care and Treatment Center (CTC) at Muhimbili National Hospital (MNH) in Dar-es-Salaam, Tanzania.

METHODS

Investigations included; interviews, physical examination and serology for HBsAg, IgG antibodies to HCV and alanine aminotransferase (ALT) levels. HIV serostatus and CD4 counts were obtained from patient records.

RESULTS

167 HIV infected children, 88(52.7%) males and 79(47.3%) females were enrolled. The overall prevalence of hepatitis co-infection was 15%, with the seroprevalence of HBV and HCV being 1.2% and 13.8%, respectively. Hepatitis virus co-infection was not associated with any of the investigated risk factors and there was no association between HBV and HCV. Elevated ALT was associated with hepatitis viral co-infection but not with ART usage or immune status.

CONCLUSION

The high seroprevalence (15%) of hepatitis co-infection in HIV infected children attending the Paediatrics HIV CTC at the MNH calls for routine screening of hepatitis viral co-infection and modification in the management of HIV infected children.

摘要

背景

随着抗生素和抗真菌药物的可及性增加,乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)感染在感染HIV的儿童中日益引起严重关注。我们确定了坦桑尼亚达累斯萨拉姆穆希姆比利国家医院(MNH)儿科HIV护理与治疗中心(CTC)18个月至17岁感染HIV儿童中HBV和HCV的血清流行率及危险因素。

方法

调查包括访谈、体格检查以及检测HBsAg、抗HCV IgG抗体和丙氨酸转氨酶(ALT)水平的血清学检查。从患者记录中获取HIV血清状态和CD4细胞计数。

结果

纳入了167名感染HIV的儿童,其中88名(52.7%)为男性,79名(47.3%)为女性。肝炎合并感染的总体患病率为15%,HBV和HCV的血清流行率分别为1.2%和13.8%。肝炎病毒合并感染与任何调查的危险因素均无关联,HBV和HCV之间也无关联。ALT升高与肝炎病毒合并感染有关,但与抗逆转录病毒治疗的使用或免疫状态无关。

结论

在MNH儿科HIV CTC就诊的感染HIV儿童中,肝炎合并感染的血清流行率较高(15%),这就需要对肝炎病毒合并感染进行常规筛查,并对感染HIV儿童的管理进行调整。

相似文献

9
Transfusion-transmissible infections among blood donors in Kathmandu, Nepal.
J Infect Dev Ctries. 2009 Dec 15;3(10):794-7. doi: 10.3855/jidc.311.
10
Viral hepatitis and rapid diagnostic test based screening for HBsAg in HIV-infected patients in rural Tanzania.
PLoS One. 2013;8(3):e58468. doi: 10.1371/journal.pone.0058468. Epub 2013 Mar 1.

引用本文的文献

5
Prevalence of and risk factors for hepatitis B and C viral co-infections in HIV infected children in Lagos, Nigeria.
PLoS One. 2020 Dec 10;15(12):e0243656. doi: 10.1371/journal.pone.0243656. eCollection 2020.
9
Seroprevalence of HBV among people living with HIV in Anyigba, Kogi State, Nigeria.
Afr Health Sci. 2019 Jun;19(2):1938-1946. doi: 10.4314/ahs.v19i2.17.

本文引用的文献

1
Hepatitis C virus genotype 4 in Ugandan children and their mothers.
Emerg Infect Dis. 2006 Sep;12(9):1440-3. doi: 10.3201/eid1209.041068.
2
Coinfection with HIV and HCV in a blood bank population in Dar es Salaam, Tanzania.
J Clin Virol. 2006 Jul;36(3):237-8. doi: 10.1016/j.jcv.2006.04.002. Epub 2006 May 24.
7
Viral coinfections among African children infected with human immunodeficiency virus type 1.
Clin Infect Dis. 2003 Apr 1;36(7):922-4. doi: 10.1086/368207. Epub 2003 Mar 19.
8
Post-transfusion hepatitis C seroprevalence in Tanzanian children.
Ann Trop Paediatr. 2001 Dec;21(4):343-8. doi: 10.1080/07430170120093535.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验