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多嵌段两亲分子的芳基氟化增强了其在脂质双层膜中的嵌入。

Aromatic Fluorination of Multiblock Amphiphile Enhances Its Incorporation into Lipid Bilayer Membranes.

机构信息

School of Life Science and Technology Tokyo Institute of Technology 4259 Nagatsuta-cho, Midori-ku, Yokohama Kanagawa 226-8501 Japan.

出版信息

ChemistryOpen. 2020 Mar 2;9(3):301-303. doi: 10.1002/open.201900374. eCollection 2020 Mar.

DOI:10.1002/open.201900374
PMID:32154050
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7050654/
Abstract

We designed multiblock amphiphiles and , which consist of perfluorinated and non-fluorinated hydrophobic units, respectively. Absorption spectroscopy revealed that both amphiphiles are molecularly dispersed in organic solvent, while they form aggregates under aqueous conditions. Furthermore, we investigated whether and can be incorporated into DOPC lipid bilayer membranes, and found that the maximum concentration of that can be incorporated into DOPC lipid bilayer membranes is 43 times higher than that of .

摘要

我们设计了多嵌段两亲分子 和 ，它们分别由全氟和非氟疏水单元组成。吸收光谱表明，两种两亲分子在有机溶剂中均以分子形式分散，而在水相条件下则形成聚集体。此外，我们还研究了 和 是否可以掺入到 DOPC 脂质双层膜中，发现可以掺入到 DOPC 脂质双层膜中的 的最大浓度是 的 43 倍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1431/7050654/f7ec32d8ffb6/OPEN-9-301-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1431/7050654/9988cf17bd14/OPEN-9-301-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1431/7050654/7756f2a68773/OPEN-9-301-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1431/7050654/8bdaa644cb0e/OPEN-9-301-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1431/7050654/f7ec32d8ffb6/OPEN-9-301-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1431/7050654/9988cf17bd14/OPEN-9-301-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1431/7050654/7756f2a68773/OPEN-9-301-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1431/7050654/8bdaa644cb0e/OPEN-9-301-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1431/7050654/f7ec32d8ffb6/OPEN-9-301-g003.jpg

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