Aromatic Fluorination of Multiblock Amphiphile Enhances Its Incorporation into Lipid Bilayer Membranes.

We designed multiblock amphiphiles and , which consist of perfluorinated and non-fluorinated hydrophobic units, respectively. Absorption spectroscopy revealed that both amphiphiles are molecularly dispersed in organic solvent, while they form aggregates under aqueous conditions. Furthermore, we investigated whether and can be incorporated into DOPC lipid bilayer membranes, and found that the maximum concentration of that can be incorporated into DOPC lipid bilayer membranes is 43 times higher than that of .