Zhang Quyan, Zhao Mingyi, Jiang Wen, Chen Chunyuan
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
Transl Pediatr. 2020 Feb;9(1):61-65. doi: 10.21037/tp.2020.01.04.
To report a case of intracranial hemorrhage in an 86-day-old boy with late-onset group B (GBS) disease and review the literature of GBS disease. Physical and auxiliary examinations and PubMed search with keywords of "GBS disease" and "intracranial hemorrhage". The 86-day-old boy was admitted to hospital for respiratory arrest. High tension in bregma indicated intracranial infection. Laboratory examination showed low red blood cell account, low white blood cell account and high C-reactive protein account. Also, GBS was positive in cerebrospinal fluid (CSF) and blood culture. Computed tomography (CT) indicated intracranial hemorrhage. Meropenem and other supportive treatment started immediately. Because of the patient's poor condition, the patient's parents abandoned the treatment. As for literature review, intracranial hemorrhage is rarely seen in late-onset disease (LOD). The case contributes to further exploration on the syndromes of GBS disease. Clinical workers should notice the complexity of bacterial infection. The relationship between polluted breast milk and infection remains to be explored.
报告一例86日龄晚发型B组链球菌(GBS)病患儿颅内出血的病例,并复习GBS病的相关文献。进行体格检查和辅助检查,并通过PubMed以“GBS病”和“颅内出血”为关键词进行检索。该86日龄男童因呼吸骤停入院。前囟张力高提示颅内感染。实验室检查显示红细胞计数低、白细胞计数低及C反应蛋白计数高。此外,脑脊液(CSF)和血培养中GBS呈阳性。计算机断层扫描(CT)显示颅内出血。立即开始使用美罗培南及其他支持治疗。由于患儿病情较差,其父母放弃治疗。至于文献复习,颅内出血在晚发型疾病(LOD)中很少见。该病例有助于进一步探索GBS病的综合征。临床工作者应注意细菌感染的复杂性。污染母乳与感染之间的关系仍有待探索。