链脲佐菌素-烟酰胺诱导的2型糖尿病大鼠模型（综述）
Streptozotocin-nicotinamide-induced rat model of type 2 diabetes (review).
作者信息
Ghasemi Asghar, Khalifi S, Jedi S
机构信息
Shahid Beheshti University of Medical Sciences Endocrine Physiology Research Center, Research Institute for Endocrine Sciences 24 Parvaneh street Velenjak, Tehran Iran PO box: 19395-4763 Shahid Beheshti University of Medical Sciences Endocrine Research Center, Research Institute for Endocrine Sciences Tehran Iran.
Shahid Beheshti University of Medical Sciences Department of Medical Laboratory Sciences, Faculty of Paramedical Sciences Tehran Iran.
出版信息
Acta Physiol Hung. 2014 Dec;101(4):408-20. doi: 10.1556/APhysiol.101.2014.4.2.
Diabetes is one of the five leading causes of death in the world, with type 2 diabetes occurring more frequently than type 1. Management of diabetes without side effects is still a challenge and therefore new strategies need to be examined. Because of difficulties in human research, animal models of diabetes are useful research tools for this purpose and rodent models of type 2 diabetes are the first choice. The aim of this study is an overview on one of the most frequently used models of type 2 diabetes in rat, induced by streptozotocin and nicotinamide, considering its advantages and disadvantages for diabetes research in humans.
糖尿病是全球五大主要死因之一，2型糖尿病的发病率高于1型糖尿病。无副作用的糖尿病管理仍然是一项挑战，因此需要研究新的策略。由于人体研究存在困难，糖尿病动物模型是用于此目的的有用研究工具，2型糖尿病啮齿动物模型是首选。本研究的目的是概述大鼠中最常用的2型糖尿病模型之一，即由链脲佐菌素和烟酰胺诱导的模型，同时考虑其在人类糖尿病研究中的优缺点。
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