Zn(ii)-cryptolepine-curcumin 分子探针在细胞凋亡检测和光动力治疗中的成像和治疗应用。
Imaging and therapeutic applications of Zn(ii)-cryptolepine-curcumin molecular probes in cell apoptosis detection and photodynamic therapy.
机构信息
Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin 537000, P. R. China.
出版信息
Chem Commun (Camb). 2020 Apr 11;56(28):3999-4002. doi: 10.1039/d0cc00524j. Epub 2020 Mar 10.
Novel red Zn(ii) complex-based fluorescent probes featuring cryptolepine-curcumin derivatives, namely, [Zn(BQ)Cl] (BQ-Zn) and [Zn(BQ)(Cur)]Cl (BQCur-Zn), were developed for the simple and fluorescent label-free detection of apoptosis, an important biological process. The probes could synergistically promote mitochondrion-mediated apoptosis and enhance tumor therapeutic effects in vitro and vivo.
新型红色 Zn(ii) 配合物荧光探针以隐丹参酮-姜黄素衍生物为配体，即 [Zn(BQ)Cl]（BQ-Zn）和 [Zn(BQ)(Cur)]Cl（BQCur-Zn），用于简单且无荧光标记的细胞凋亡检测，细胞凋亡是一种重要的生物学过程。该探针可以协同促进线粒体介导的细胞凋亡，并增强体外和体内的肿瘤治疗效果。
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