Division of Cancer Prevention, National Cancer Institute, Rockville, MD, USA.
Expert Rev Clin Pharmacol. 2020 Mar;13(3):265-285. doi: 10.1080/17512433.2020.1738218. Epub 2020 Apr 3.
: Naturally occurring compounds play an essential role in the prevention and treatment of various cancers. There are more than 100 plant and animal based natural compounds currently in clinical use.: 1) The importance of natural products combinations in the prevention and treatment of cancer, 2) the need to maximize efficacy while minimizing side effects when using natural product combinations, and 3) specifics related to plant and animal derived natural products, as well as agents derived from natural products. Therapies using natural compounds that have been investigated, their rationale, mechanism of action and findings are reviewed. When the data warrant it, combined interventions that appear to increase efficacy (compared with monotherapy) while minimizing toxicity have been highlighted. Pubmed was used to search for relevant publications.: Combination therapy with natural compounds has the potential to be more effective than single agent therapy. Similar to pharmacologic agents, the goal is to maximize efficacy while mimimizing potential side effects. There is an increasing research focus on the development of agents derived from natural products, with notable successes already achieved from the effort.
天然化合物在预防和治疗各种癌症方面起着至关重要的作用。目前有超过 100 种基于植物和动物的天然化合物正在临床应用中。1）天然产物组合在癌症预防和治疗中的重要性，2）在使用天然产物组合时最大限度地提高疗效同时最小化副作用的需要，以及 3）与植物和动物来源的天然产物以及天然产物衍生的制剂相关的具体信息。综述了已研究过的使用天然化合物的疗法、其原理、作用机制和发现。当数据证明合理时，突出了那些似乎能提高疗效（与单药治疗相比）同时最小化毒性的联合干预措施。使用 Pubmed 搜索相关出版物。
天然化合物的联合治疗可能比单一药物治疗更有效。与药理制剂类似，目标是最大限度地提高疗效，同时最大限度地减少潜在的副作用。人们越来越关注从天然产物中开发制剂，已经取得了显著的成功。
