Nunes Aline, Rilievo Graziano, Magro Massimiliano, Maraschin Marcelo, Vianello Fabio, Lima Giuseppina Pace Pereira
Department of Chemical and Biological Sciences, Institute of Biosciences, São Paulo State University, Botucatu 18618-970, São Paulo, Brazil.
Department of Comparative Biomedicine and Food Science, University of Padova, Viale dell'Università 16, 35020 Legnaro, Padua, Italy.
Int J Mol Sci. 2025 Apr 30;26(9):4275. doi: 10.3390/ijms26094275.
Green synthesized nanoparticles (NPs) are arousing constantly increasing attention due to inherent advantages such as biocompatibility, nontoxicity, and cost-effectiveness. As the state of the art of this rapidly evolving topic demands a punctual update, the present study was focused on reviewing the novelty, feasibility, and effectiveness related to the specific category of red seaweed-derived NPs. Among algae, red seaweeds have already gained consideration in the global market due to their high content of primary and secondary metabolites, supporting multifunctional applications across various industries. This scoping review reveals how this interest has also driven their investigation as a natural source for the sustainable NP fabrication. The fragmentary body of studies was synthesized, identifying red seaweed NPs as a flourishing nanotechnological subgroup and meriting their own space in the scientific literature. Noteworthy, the great majority of the reviewed papers feature efficient controlled release, enhanced bioavailability, and reduced toxicity, making red seaweed NPs elective candidates for the medical sector as anticancer, antimicrobial, and antioxidant agents. Moreover, their parent natural counterparts seem to endow NPs with unexpected specificity toward biological targets such as prokaryotic and tumor cells. Nanotechnological solutions based on red seaweeds pave the way to a new avenue of opportunities and challenges.
绿色合成纳米颗粒（NPs）因其生物相容性、无毒性和成本效益等固有优势而受到越来越多的关注。由于这一快速发展的主题需要及时更新，本研究重点回顾了与红海藻衍生纳米颗粒这一特定类别相关的新颖性、可行性和有效性。在藻类中，红海藻因其初级和次级代谢产物含量高，在全球市场上已受到关注，支持跨行业的多功能应用。这一范围界定综述揭示了这种兴趣如何也推动了对其作为可持续纳米颗粒制造天然来源的研究。对零散的研究进行了综合，将红海藻纳米颗粒确定为一个蓬勃发展的纳米技术亚组，在科学文献中值得拥有自己的一席之地。值得注意的是，绝大多数综述论文都具有高效控释、提高生物利用度和降低毒性的特点，使红海藻纳米颗粒成为医疗领域抗癌、抗菌和抗氧化剂的理想候选物。此外，它们的天然母体似乎赋予纳米颗粒对原核细胞和肿瘤细胞等生物靶点意想不到的特异性。基于红海藻的纳米技术解决方案为新的机遇和挑战开辟了道路。
