Department of Respiratory and Critical Care Medicine, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Department of Tuberculosis, Shijiazhuang Fifth Hospital, Hebei, China.
Thorac Cancer. 2020 May;11(5):1334-1338. doi: 10.1111/1759-7714.13385. Epub 2020 Mar 10.
Lambert-Eaton myasthenic syndrome (LEMS) is a rare disease characterized by involvement of the neuromuscular junction. Most cases have an underlying malignancy, especially small-cell lung cancer (SCLC), while adenocarcinoma is less common. Here, we report a rare case of metastatic lung adenocarcinoma complicated with LEMS. In this case, L858R mutation was detected in the 21st exon of the EGFR gene. First-line treatment with gefitinib was given, and the patient has survived for more than six years. Early diagnosis of LEMS and timely and effective treatment can result in a good prognosis. We also searched for "lung cancer", or "carcinoma of lung", or "adenocarcinoma of lung", or "Lambert-Eaton myasthenic syndrome" in PubMed until 1 December 2019. Seven cases of lung adenocarcinoma complicated with LEMS were found, most of which had a poor prognosis. KEY POINTS: This article reports a rare case of metastatic lung adenocarcinoma with EGFR mutation, complicated with LEMS. Gefitinib was given as first-line treatment, and resulted in a good prognosis.
Lambert-Eaton 肌无力综合征（LEMS）是一种以神经肌肉接头受累为特征的罕见疾病。大多数病例有潜在的恶性肿瘤，特别是小细胞肺癌（SCLC），而腺癌则较少见。在这里，我们报告一例转移性肺腺癌合并 LEMS 的罕见病例。在该病例中，检测到 EGFR 基因第 21 外显子的 L858R 突变。给予吉非替尼一线治疗，患者已存活超过六年。早期诊断 LEMS 并及时有效治疗可获得良好预后。我们还在 PubMed 中以“lung cancer”、“carcinoma of lung”、“adenocarcinoma of lung”或“Lambert-Eaton myasthenic syndrome”为检索词进行搜索，截至 2019 年 12 月 1 日，共发现 7 例合并 LEMS 的肺腺癌病例，大多数预后较差。
本文报告一例罕见的伴有 EGFR 突变的转移性肺腺癌合并 LEMS 的病例。给予吉非替尼一线治疗，取得了良好的预后。
