Department of Chemistry, The Ohio State University, 100W. 18th Ave., Columbus, Ohio, 43210, USA.
Chemistry. 2020 Jul 14;26(39):8572-8578. doi: 10.1002/chem.202000403. Epub 2020 Jun 18.
The susceptibility of self-assembled materials to changes of environmental conditions and mechanical forces often limits their utility for many applications. In this work, the surface of nanofibers formed by β-sheet peptide self-assemblies were coated by polydopamine (PDA) deposition. This conformal coating process rendered the nanofiber dimensions and internal π-stacking chirality impervious to changes in pH, temperature, and physical processing by spin-coating onto a silicon wafer. Whereas sonication-induced shearing of the dopamine/naphthalenediimide-dilysine (DA/NDI-KK) composite irreversibly shortened the nanofibers into 100-200 nm segments, the uncoated nanofibers unraveled into single strands upon similar treatment. Additionally, the PDA-coated nanofibers could be wrapped by an additional layer comprised of a positively charged polyelectrolyte polymer.
自组装材料对环境条件和机械力变化的敏感性常常限制了它们在许多应用中的实用性。在这项工作中，通过聚多巴胺 (PDA) 沉积对由 β-折叠肽自组装形成的纳米纤维的表面进行了涂层处理。这种共形涂层过程使得纳米纤维的尺寸和内部π堆积手性不受 pH 值、温度和通过旋涂到硅晶片上的物理处理的变化的影响。而超声诱导的多巴胺/萘二酰亚胺-赖氨酸（DA/NDI-KK）复合材料的剪切会不可逆地将纳米纤维缩短成 100-200nm 的片段，而未涂层的纳米纤维在类似的处理下会解开成单链。此外，PDA 涂层的纳米纤维可以被由带正电荷的聚电解质聚合物组成的额外层包裹。
