Institute of Organic Chemistry III/Macromolecular Chemistry, Ulm University, Albert-Einstein-Allee 11, 89081, Ulm, Germany.
Department Synthesis of Macromolecules, Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
Adv Healthc Mater. 2018 Jun;7(11):e1701485. doi: 10.1002/adhm.201701485. Epub 2018 Apr 10.
Hybrid nanomaterials have shown great potential in regenerative medicine due to the unique opportunities to customize materials properties for effectively controlling cellular growth. The peptide nanofiber-mediated auto-oxidative polymerization of dopamine, resulting in stable aqueous dispersions of polydopamine-coated peptide hybrid nanofibers, is demonstrated. The catechol residues of the polydopamine coating on the hybrid nanofibers are accessible and provide a platform for introducing functionalities in a pH-responsive polymer analogous reaction, which is demonstrated using a boronic acid modified fluorophore. The resulting hybrid nanofibers exhibit attractive properties in their cellular interactions: they enhance neuronal cell adhesion, nerve fiber growth, and growth cone area, thus providing great potential in regenerative medicine. Furthermore, the facile modification by pH-responsive supramolecular polymer analog reactions allows tailoring the functional properties of the hybrid nanofibers in a reversible fashion.
杂化纳米材料在再生医学中显示出巨大的潜力，因为它们具有独特的机会来定制材料性能，从而有效地控制细胞生长。本文展示了通过肽纳米纤维介导的多巴胺自氧化聚合，得到稳定的聚多巴胺包覆肽杂化纳米纤维水相分散体。杂化纳米纤维上的聚多巴胺涂层的儿茶酚残基是可及的，并为在 pH 响应聚合物类似反应中引入功能提供了一个平台，这在使用硼酸修饰的荧光染料时得到了证明。所得的杂化纳米纤维在其细胞相互作用中表现出吸引人的性质：它们增强神经元细胞的黏附、神经纤维的生长和生长锥的面积，因此在再生医学中具有巨大的潜力。此外，通过 pH 响应超分子聚合物类似反应的简便修饰，可以以可逆的方式定制杂化纳米纤维的功能特性。
