Sarkari Soulmaz, Khajehmohammadi Mehran, Davari Niyousha, Li Dejian, Yu Baoqing
Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Department of Mechanical Engineering, Faculty of Engineering, Yazd University, Yazd, Iran.
Front Bioeng Biotechnol. 2022 Sep 12;10:1005413. doi: 10.3389/fbioe.2022.1005413. eCollection 2022.
The biomaterials' success within the tissue engineering field is hinged on the capability to regulate tissue and cell responses, comprising cellular adhesion, as well as repair and immune processes' induction. In an attempt to enhance and fulfill these biomaterials' functions, scholars have been inspired by nature; in this regard, surface modification via coating the biomaterials with polydopamine is one of the most successful inspirations endowing the biomaterials with surface adhesive properties. By employing this approach, favorable results have been achieved in various tissue engineering-related experiments, a significant one of which is the more rapid cellular growth observed on the polydopamine-coated substrates compared to the untreated ones; nonetheless, some considerations regarding polydopamine-coated surfaces should be taken into account to control the ultimate outcomes. In this mini-review, the importance of coatings in the tissue engineering field, the different types of surfaces requiring coatings, the significance of polydopamine coatings, critical factors affecting the result of the coating procedure, and recent investigations concerning applications of polydopamine-coated biomaterials in tissue engineering are thoroughly discussed.
生物材料在组织工程领域的成功取决于其调节组织和细胞反应的能力，包括细胞黏附以及诱导修复和免疫过程。为了增强并实现这些生物材料的功能，学者们从自然中获得了灵感；在这方面，通过用聚多巴胺包覆生物材料进行表面改性是最成功的灵感之一，它赋予了生物材料表面黏附特性。采用这种方法，在各种与组织工程相关的实验中都取得了良好的效果，其中一个重要的结果是，与未处理的底物相比，在聚多巴胺包覆的底物上观察到细胞生长更快；然而，为了控制最终结果，应考虑一些关于聚多巴胺包覆表面的因素。在这篇小型综述中，将全面讨论涂层在组织工程领域的重要性、需要涂层的不同类型表面、聚多巴胺涂层的意义、影响涂层过程结果的关键因素以及关于聚多巴胺包覆生物材料在组织工程中应用的最新研究。
