Baraka Adam, Traglia German M, Montaña Sabrina, Tolmasky Marcelo E, Ramirez Maria Soledad
Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, CA 92831, USA.
Departamento de Desarrollo Biotecnológico, Instituto de Higiene, Facultad de Medicina, Universidad de la República, MVD, Montevideo 11800, Uruguay.
Antibiotics (Basel). 2020 Dec 26;10(1):16. doi: 10.3390/antibiotics10010016.
non- species are becoming common etiologic agents of nosocomial infections. Furthermore, clinical isolates belonging to this group of bacteria are usually resistant to one or more antibiotics. The current information about antibiotic resistance genes in the different non- species has not yet been studied as a whole. Therefore, we did a comparative study of the resistomes of non- pathogens based on information available in published articles and genome sequences. We searched the available literature and sequences deposited in GenBank to identify the resistance gene content of , , , , , , , , , , , , , , , , , , , , and The most common genes were those coding for different β-lactamases, including the carbapenemase genes and . was the species with the most β-lactamase resistance genes reported. Other genes that were commonly found include those encoding some aminoglycoside modifying enzymes, the most common being , , and , and efflux pumps. All or part of the genes coding for the AdeABC, AdeFGH, and AdeIJK efflux pumps were the most commonly found. This article incorporates all the current information about non- resistance genes. The comparison of the different resistomes shows that there are similarities in the genes present, but there are also significant differences that could impact the efficiency of treatments depending on the etiologic agent. This article is a comprehensive resource about non- resistomes.
非[具体菌名]属正成为医院感染的常见病原体。此外，属于这组细菌的临床分离株通常对一种或多种抗生素耐药。目前关于不同非[具体菌名]属中抗生素耐药基因的信息尚未进行全面研究。因此，我们基于已发表文章和基因组序列中的可用信息，对非[具体菌名]属病原体的耐药组进行了比较研究。我们检索了现有文献以及GenBank中保存的序列，以确定[多个菌名]的耐药基因内容。最常见的基因是编码不同β-内酰胺酶的基因，包括碳青霉烯酶基因[具体基因名]和[具体基因名]。[具体菌名]是报告中β-内酰胺酶耐药基因最多的菌种。其他常见的基因包括那些编码一些氨基糖苷修饰酶的基因，最常见的是[具体基因名]、[具体基因名]和[具体基因名]，以及外排泵。编码AdeABC、AdeFGH和AdeIJK外排泵的全部或部分基因是最常发现的。本文纳入了关于非[具体菌名]属耐药基因的所有当前信息。不同耐药组的比较表明，存在的基因有相似之处，但也存在显著差异，这可能会根据病原体影响治疗效果。本文是关于非[具体菌名]属耐药组的综合资源。
