Geraci Marco, Farcomeni Alessio
Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Department of Economics and Finance, University of Rome "Tor Vergata", Rome, Italy.
Stat Methods Med Res. 2020 Sep;29(9):2665-2682. doi: 10.1177/0962280220903763. Epub 2020 Mar 11.
We propose a new family of linear mixed-effects models based on the generalized Laplace distribution. Special cases include the classical normal mixed-effects model, models with Laplace random effects and errors, and models where Laplace and normal variates interchange their roles as random effects and errors. By using a scale-mixture representation of the generalized Laplace, we develop a maximum likelihood estimation approach based on Gaussian quadrature. For model selection, we propose likelihood ratio testing and we account for the situation in which the null hypothesis is at the boundary of the parameter space. In a simulation study, we investigate the finite sample properties of our proposed estimator and compare its performance to other flexible linear mixed-effects specifications. In two real data examples, we demonstrate the flexibility of our proposed model to solve applied problems commonly encountered in clustered data analysis. The newly proposed methods discussed in this paper are implemented in the R package nlmm.
我们提出了一个基于广义拉普拉斯分布的新型线性混合效应模型族。特殊情况包括经典正态混合效应模型、具有拉普拉斯随机效应和误差的模型,以及拉普拉斯和正态变量作为随机效应和误差互换角色的模型。通过使用广义拉普拉斯的尺度混合表示,我们开发了一种基于高斯求积的最大似然估计方法。对于模型选择,我们提出似然比检验,并考虑原假设位于参数空间边界的情况。在一项模拟研究中,我们研究了所提出估计量的有限样本性质,并将其性能与其他灵活的线性混合效应规格进行比较。在两个实际数据示例中,我们展示了所提出模型解决聚类数据分析中常见应用问题的灵活性。本文讨论的新提出方法在R包nlmm中实现。