Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100048, China.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100048, China.
Food Res Int. 2020 Apr;130:108933. doi: 10.1016/j.foodres.2019.108933. Epub 2019 Dec 23.
Advance glycation end products (AGEs) are a diverse group of compounds formed through the non-enzymatic maillard reaction of reducing sugars with the free amino groups in proteins, lipids or nucleic acids. Accumulation of AGEs has been suggested to be a pathogenic mechanism of oxidative stress, inflammation and structural tissue damage leading to chronic vascular problems in many ailments including diabetes, atherosclerosis, neuropathy, retinopathy, nephropathy, aging, and chronic renal disease. Treatment with AGEs inhibitors is believed to be a potential strategy for preventing lifestyle-related diseases. To inhibit the AGEs development is supposed to show part in the inhibition of diabetic problems. Study of dietary bioactive combinations with antiglycation properties delivers future views for inhibition or mediation associated to AGEs complications. Many study show the possibility of dietary constituents to stop AGE development. Therefore, search for natural compounds able to prevent glycation and have the potential therapeutic ability to inhibit diabetes and age associated diseases. The purpose of this review is to critically evaluate the existing literature on different phenolics on AGEs inhibition.
糖基化终产物（AGEs）是通过还原糖与蛋白质、脂质或核酸中的游离氨基之间的非酶促美拉德反应形成的一组多样化的化合物。有人认为，AGEs 的积累是导致氧化应激、炎症和结构组织损伤的致病机制，从而导致包括糖尿病、动脉粥样硬化、神经病、视网膜病变、肾病、衰老和慢性肾病在内的许多疾病的慢性血管问题。用 AGEs 抑制剂治疗被认为是预防与生活方式相关疾病的一种潜在策略。抑制 AGEs 的发展被认为在抑制糖尿病问题方面发挥了作用。研究具有抗糖化特性的饮食生物活性组合为抑制或介导与 AGEs 并发症相关的问题提供了未来的观点。许多研究表明膳食成分有阻止 AGE 发展的可能性。因此，寻找能够预防糖化并具有抑制糖尿病和与年龄相关疾病的潜在治疗能力的天然化合物。本综述的目的是批判性地评估关于不同酚类物质对 AGEs 抑制作用的现有文献。
