Hariu Tomoki, Furutani Akinobu, Yamasaki Shigeki, Kitade Takashi, Wakasa Motomi, Sonoyama Teruhisa
Dept. of Digestive Surgery, Shotokai Irie Hospital.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2243-2245.
The pathological condition which causes cerebrovascular disease through hypercoagulability associated with malignant tumors is known as Trousseau syndrome. Here, we report the case of a patient with Trousseau syndrome which developed as a complication during chemotherapy for advanced gastric cancer. A 70-year-old woman with multiple lymph node metastases of gastric cancer underwent TS-1 plus CDDP chemotherapy before surgery. She had symptoms of left hemiparesis during the first course of chemotherapy. She was diagnosed with acute cerebralinfarction using brain MRI, and blood tests indicated hypercoagulability. Therefore, it was strongly suspected that she had Trousseau syndrome. A total of 2 courses of chemotherapy were administered, along with anticoagulation therapy with edoxaban. She exhibited improved paralysis and received a totalgastrectomy after chemotherapy. According to recent reports, more than 90% of patients with malignant tumors have hypercoagulability, and more than 50% of them have thromboembolisms. It is therefore essential to obtain early diagnosis and provide anticoagulation therapy for cerebral infarction, and to provide treatment against malignant diseases in patients with Trousseau syndrome.
通过与恶性肿瘤相关的高凝状态导致脑血管疾病的病理状况被称为特鲁索综合征。在此，我们报告一例特鲁索综合征患者，该综合征是晚期胃癌化疗期间出现的并发症。一名患有胃癌多发淋巴结转移的70岁女性在手术前接受了替吉奥联合顺铂化疗。在第一个化疗疗程中，她出现了左侧偏瘫症状。通过脑部MRI诊断为急性脑梗死，血液检查显示存在高凝状态。因此，强烈怀疑她患有特鲁索综合征。总共进行了2个疗程的化疗，并使用依度沙班进行抗凝治疗。她的瘫痪症状有所改善，化疗后接受了全胃切除术。根据最近的报道，超过90%的恶性肿瘤患者存在高凝状态，其中超过50%的患者发生血栓栓塞。因此，对于脑梗死必须尽早诊断并提供抗凝治疗，对于特鲁索综合征患者还需针对恶性疾病进行治疗。
