Patel Bhuvic, Kim Albert H
Albert H. Kim, MD, PhD, MSMA member since 2011, is Director, Brain Tumor Program, Associate Professor of Neurological Surgery, Genetics, Neurology, and Developmental Biology, and Bhuvic Patel, MD, Neurosurgery Resident PGY5, Department of Neurosurgery, Washington University School of Medicine, St. Louis, Missouri.
Mo Med. 2020 Jan-Feb;117(1):50-55.
Laser interstitial thermal therapy (LITT) is a minimally invasive and cytoreductive neurosurgical technique that has gained significant momentum in the last decade. Several technological enhancements such as MRI thermometry and improved laser probe design have enabled feasibility and improved the safety of LITT procedures. Numerous reports have been published describing the treatment of lesions ranging from tumors to epileptogenic foci, but the indications for LITT continue to evolve. We describe the general physical and biological concepts underlying LITT, clinical workflow, and established and emerging indications.
激光间质热疗（LITT）是一种微创性和细胞减灭性神经外科技术，在过去十年中获得了显著发展。诸如MRI温度测量和改进的激光探头设计等多项技术进步，使得LITT手术具备了可行性并提高了安全性。已经发表了大量报告，描述了从肿瘤到致痫灶等各种病变的治疗情况，但LITT的适应证仍在不断演变。我们阐述了LITT背后的一般物理和生物学概念、临床工作流程以及已确立和新出现的适应证。
