Dadey David Y A, Kamath Ashwin A, Leuthardt Eric C, Smyth Matthew D
Department of Neurological Surgery and.
Medical Scientist Training Program, Washington University School of Medicine, St. Louis, Missouri.
Neurosurg Focus. 2016 Oct;41(4):E9. doi: 10.3171/2016.7.FOCUS16231.
Subependymal giant cell astrocytoma (SEGA) is a rare tumor occurring almost exclusively in patients with tuberous sclerosis complex. Although open resection remains the standard therapy, complication rates remain high. To minimize morbidity, less invasive approaches, such as endoscope-assisted resection, radiosurgery, and chemotherapy with mTOR pathway inhibitors, are also used to treat these lesions. Laser interstitial thermal therapy (LITT) is a relatively new modality that is increasingly used to treat a variety of intracranial lesions. In this report, the authors describe two pediatric cases of SEGA that were treated with LITT. In both patients the lesion responded well to this treatment modality, with tumor shrinkage observed on follow-up MRI. These cases highlight the potential of LITT to serve as a viable minimally invasive therapeutic approach to the management of SEGAs in the pediatric population.
室管膜下巨细胞星形细胞瘤（SEGA）是一种罕见肿瘤，几乎仅发生于结节性硬化症患者。尽管开放切除术仍是标准治疗方法，但并发症发生率仍然很高。为了将发病率降至最低，也采用侵入性较小的方法，如内镜辅助切除术、放射外科手术以及使用mTOR通路抑制剂进行化疗来治疗这些病变。激光间质热疗（LITT）是一种相对较新的治疗方式，越来越多地用于治疗各种颅内病变。在本报告中，作者描述了两例接受LITT治疗的儿童SEGA病例。两名患者的病变对这种治疗方式反应良好，随访MRI显示肿瘤缩小。这些病例凸显了LITT作为一种可行的微创治疗方法来管理儿童SEGA的潜力。
