Sousa Keissy, Calvão-Santos Gil, João Marina, Gomes Nuno, Falcão Manuel
Retina Department of Hospital de Braga, Braga, Portugal.
Ophthalmology Department of Hospital de Braga, Braga, Portugal.
Clin Ophthalmol. 2020 Feb 25;14:525-531. doi: 10.2147/OPTH.S232202. eCollection 2020.
Subthreshold micropulse laser treatment with a 532 nm (532-SML) wavelength has been suggested as a treatment option for the treatment of chronic central serous retinopathy (cCSR). The objective is to present its effects and complications.
We present a retrospective cohort study of cCSR patients submitted to 532-SML. Best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (SD-OCT) parameters - central macular thickness, subfoveal outer nuclear layer, external limiting membrane, ellipsoid band, interdigitation band, subretinal fluid and choroidal thickness - were evaluated before and 12 weeks after treatment. A power of 50%, a duty cycle of 5%, exposure time of 200 ms and a spot size of 160 µm were the applied laser parameters.
We included 26 eyes. Overall there were no significant changes in visual acuity (median 0.20 (IQR 0) logMAR before and after treatment) or SD-OCT parameters. However, visual benefits occurred in 42.3% (n=11) of the patients and in half of the cases, subretinal fluid was completely reabsorbed. There were no complications.
In this study, 532-SML was overall ineffective on cCSR as it did not lead to significant changes in the overall median visual acuity and SD-OCT parameters. However, some patients may have benefited functionally and anatomically from the treatment; further investigation is necessary to understand the potential of 532-SML.
波长为532nm的阈下微脉冲激光治疗（532-SML）已被提议作为慢性中心性浆液性脉络膜视网膜病变（cCSR）的一种治疗选择。目的是呈现其疗效和并发症。
我们对接受532-SML治疗的cCSR患者进行了一项回顾性队列研究。在治疗前和治疗后12周评估最佳矫正视力（BCVA）和光谱域光学相干断层扫描（SD-OCT）参数——中心黄斑厚度、黄斑中心凹外核层、外界膜、椭圆体带、指状交叉带、视网膜下液和脉络膜厚度。应用的激光参数为功率50%、占空比5%、曝光时间200ms和光斑大小160µm。
我们纳入了26只眼。总体而言，视力（治疗前后的中位数为0.20（四分位间距0）logMAR）或SD-OCT参数没有显著变化。然而，42.3%（n = 11）的患者视力有改善，并且在一半的病例中，视网膜下液完全吸收。没有并发症发生。
在本研究中，532-SML对cCSR总体无效，因为它未导致总体中位数视力和SD-OCT参数发生显著变化。然而，一些患者可能在功能和解剖学上从治疗中获益；有必要进一步研究以了解532-SML的潜力。
