Gegin Savas, Celikel Serhat, Celik Deniz, Pazarli Ahmet Cemal
Department of Pulmonary Diseases, University of Health Sciences, Samsun Training and Research Hospital, Samsun, Turkey.
Department of Pulmonary Diseases, İstanbul Medipol University, İstanbul, Turkey.
Eurasian J Med. 2020 Feb;52(1):25-28. doi: 10.5152/eurasianjmed.2019.19181.
If systemic inflammation in relation with obesity causes asthma, the detection of increased airway inflammation among obese individuals who do not have any respiratory symptoms can be also beneficial in indentifying obese patients who are at risk of developing asthma. The aim of this study was to evaluate the systemic and airway inflammation of asymptomatic obese and non-obese individuals.
Obese and non-obese individuals with no respiratory symptoms were included. Inflammatory biomarkers such as C-reactive protein (CRP), exhaled breath condensate (EBC) interleukin-6 (IL-6), EBC leukotriene B-4 (LTB-4), and EBC nitric oxide (NO) levels of obese and non-obese individuals were determined.
Forty-five obese individuals (body mass index [BMI]≥30) and 31 non-obese individuals (BMI≤25) as a control group were included in this study. The mean age of the obese group (38.7±11.4 years) was significantly higher than the one of the non-obese group (29.5±8.6 years; p<0.001). There was no significant relationship between gender and BMI (χ =1.471, p=0.225). CRP levels were significantly higher in the obese group (6.94±8.28) than the non-obese group (3.29±0.39; p<0.001). The levels of EBC IL-6 in obese and non-obese group were found as 22.61±12.53 and 21.08±14.39, respectively (p=0.624). There was no significant difference between EBC NO levels of the obese group and non-obese group (24.35±10.9 vs. 21.56±7.83; p=0.226). No significant difference was found between the EBC LTB-4 level in the obese group and the non-obese group (36.39±89.82 vs. 16.64±17.45; p=0.231).
Increased systemic inflammation in obese individuals who had no respiratory symptoms might indicate the tendency of asthma. However, airway inflammation was not significantly different between groups. Therefore the relationship between obesity and asthma should be investigated in future large-scale studies determining the direct effects of adipokines on airways.
如果与肥胖相关的全身炎症会引发哮喘，那么在没有任何呼吸道症状的肥胖个体中检测气道炎症增加，对于识别有患哮喘风险的肥胖患者也可能有益。本研究的目的是评估无症状肥胖和非肥胖个体的全身及气道炎症。
纳入无呼吸道症状的肥胖和非肥胖个体。测定肥胖和非肥胖个体的炎症生物标志物，如C反应蛋白（CRP）、呼出气冷凝液（EBC）白细胞介素-6（IL-6）、EBC白三烯B-4（LTB-4）和EBC一氧化氮（NO）水平。
本研究纳入45名肥胖个体（体重指数[BMI]≥30）和31名非肥胖个体（BMI≤25）作为对照组。肥胖组的平均年龄（38.7±11.4岁）显著高于非肥胖组（29.5±8.6岁；p<0.001）。性别与BMI之间无显著关系（χ =1.471，p=0.225）。肥胖组的CRP水平（6.94±8.28）显著高于非肥胖组（3.29±0.39；p<0.001）。肥胖组和非肥胖组的EBC IL-6水平分别为22.61±12.53和21.08±14.39（p=0.624）。肥胖组和非肥胖组的EBC NO水平无显著差异（24.35±10.9对21.56±7.83；p=0.226）。肥胖组和非肥胖组的EBC LTB-4水平无显著差异（36.39±89.82对16.64±17.45；p=0.231）。
没有呼吸道症状的肥胖个体全身炎症增加可能表明有患哮喘的倾向。然而，两组之间的气道炎症无显著差异。因此，未来应通过大规模研究来调查肥胖与哮喘之间的关系，确定脂肪因子对气道的直接影响。
