Miyoshi Yoko, Morizane Shuichi, Honda Masashi, Hikita Katsuya, Iwamoto Hideto, Yumioka Tetsuya, Kimura Yusuke, Yoshioka Shin-Ichi, Takenaka Atsushi
Department of Adult and Elderly Nursing, School of Health Science, Tottori University Faculty of Medicine, Yonago 683-8503, Japan.
Department of Urology, Tottori University Hospital, Yonago 683-8504, Japan.
Yonago Acta Med. 2020 Jan 30;63(1):55-62. doi: 10.33160/yam.2020.02.008. eCollection 2020 Feb.
Radical prostatectomy and radiotherapy are standard treatments for localized prostate cancer. When making decisions about treatment, it is important to not only consider medical information such as the patient's age, performance status, and complications, but also the impact on quality of life (QOL) after treatment.
Our purpose was to compare health related quality of life (HRQOL) after robot-assisted laparoscopic radical prostatectomy (RARP) versus radiation therapy in Japanese patients with localized prostate cancer retrospectively.
Patients with localized prostate cancer receiving RARP or radiotherapy at Tottori University Hospital between October 2010 and December 2014 were enrolled in a retrospective observational study with follow-up for 24 months to December 2016. The Medical Outcome Study 8-Item Short-Form Health Survey was performed before treatment and 1, 3, 6, 12, and 24 months post-treatment.
Complete responses to the questionnaire were obtained from 154/227 patients receiving RARP, 41/67 patients receiving intensity-modulated radiation therapy, 35/82 patients receiving low dose rate brachytherapy, and 18/28 patients given low dose rate brachytherapy plus external beam radiation therapy. The median physical component summary score of the Medical Outcome Study 8-Item Short-Form Health Survey was significantly lower at 1 month after prostatectomy than radiotherapy, but was similar for both treatments at 3 months, and was significantly higher at 6, 12 and 24 months after prostatectomy. The median mental component summary score was also significantly lower in the prostatectomy group at 1 month, but not from 3 months onwards.
Our study suggested that HRQOL was inferior at 1 month after RARP, however, recovered at 3 months after RARP and was better than after radiotherapy at 6, 12, and 24 months.
根治性前列腺切除术和放射治疗是局限性前列腺癌的标准治疗方法。在做出治疗决策时，不仅要考虑患者年龄、身体状况和并发症等医学信息，还要考虑治疗后对生活质量（QOL）的影响。
我们的目的是回顾性比较日本局限性前列腺癌患者接受机器人辅助腹腔镜根治性前列腺切除术（RARP）与放射治疗后的健康相关生活质量（HRQOL）。
2010年10月至2014年12月在鸟取大学医院接受RARP或放射治疗的局限性前列腺癌患者被纳入一项回顾性观察研究，随访至2016年12月共24个月。在治疗前以及治疗后1、3、6、12和24个月进行医学结果研究8项简表健康调查。
分别从154/227例接受RARP的患者、41/67例接受调强放射治疗的患者、35/82例接受低剂量率近距离放射治疗的患者以及18/28例接受低剂量率近距离放射治疗加外照射治疗的患者中获得了对问卷的完整回复。医学结果研究8项简表健康调查的身体成分总结得分中位数在前列腺切除术后1个月时显著低于放射治疗，但在3个月时两种治疗相似，且在前列腺切除术后6、12和24个月时显著更高。精神成分总结得分中位数在前列腺切除术组1个月时也显著更低，但从3个月起则无差异。
我们的研究表明，RARP术后1个月时HRQOL较差，但在RARP术后3个月恢复，且在6、12和24个月时优于放射治疗后。
