Seetohul Yanish Bhashkar, Singh Vishwambhar, Jain Rajiv Kumar, Chaudhary Ashvanee Kumar
Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttarpradesh India.
Indian J Otolaryngol Head Neck Surg. 2020 Mar;72(1):128-132. doi: 10.1007/s12070-019-01771-2. Epub 2019 Nov 25.
To study the prognostic significance of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in head and neck cancers. The study included 170 cases of histopathologically diagnosed head and neck cancer patients and 80 control subjects. NLR and PLR of patients with head and neck cancers were compared to the control group. The correlation between NLR and PLR values and factors such as age, gender, duration of symptoms, site of tumour, histological type, histological grading, T-category, N-category and TNM stages in cancer patients were analysed. NLR and PLR were statistically higher in cancer patients compared to control. There was a non-significant increase in both NLR and PLR with advancing degree of differentiation and TNM Stages of the cancer patients. A significant increase in NLR and PLR with increasing T Categories and increasing N Categories of head and neck cancer patients was obtained. NLR and PLR can be used to estimate tumour prognosis in head and neck cancers. Increased NLR and PLR values can be used as a marker for poor prognosis. However further studies with larger study groups including treatment response and surveillance should be carried out to corroborate these results.
研究中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）在头颈癌中的预后意义。该研究纳入了170例经组织病理学诊断的头颈癌患者和80例对照受试者。将头颈癌患者的NLR和PLR与对照组进行比较。分析了癌症患者的NLR和PLR值与年龄、性别、症状持续时间、肿瘤部位、组织学类型、组织学分级、T分期、N分期和TNM分期等因素之间的相关性。与对照组相比，癌症患者的NLR和PLR在统计学上更高。随着癌症患者分化程度和TNM分期的进展，NLR和PLR均有非显著性增加。随着头颈癌患者T分期和N分期的增加，NLR和PLR显著增加。NLR和PLR可用于评估头颈癌的肿瘤预后。NLR和PLR值升高可作为预后不良的标志物。然而，需要开展包括治疗反应和监测在内的更大样本量研究以证实这些结果。
