Wen Hairuo, Gwathmey Judith K, Xie Lai-Hua
Beijing Key Laboratory, National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, Beijing, China.
Department of Cell Biology and Molecular Medicine, Rutgers University-New Jersey Medical School, Newark, NJ, United States.
Front Cardiovasc Med. 2020 Feb 25;7:24. doi: 10.3389/fcvm.2020.00024. eCollection 2020.
Transient receptor potential canonical (TRPC) channels are involved in the regulation of cardiac function under (patho)physiological conditions and are closely associated with the pathogenesis of cardiac hypertrophy, arrhythmias, and myocardial infarction. Understanding the molecular mechanisms and the regulatory pathway/locus of TRPC channels in related heart diseases will provide potential new concepts for designing novel drugs targeting TRPC channels. We will present the properties and regulation of TRPC channels and their roles in the development of various forms of heart disease. This article provides a brief review on the role of TRPC channels in the regulation of myocardial function as well as how TRPC channels may serve as a therapeutic target in heart failure and cardiac arrhythmias including atrial fibrillation.
瞬时受体电位香草酸亚型（TRPC）通道参与（病理）生理条件下心脏功能的调节，并且与心肌肥大、心律失常和心肌梗死的发病机制密切相关。了解TRPC通道在相关心脏疾病中的分子机制以及调节途径/位点，将为设计靶向TRPC通道的新型药物提供潜在的新概念。我们将介绍TRPC通道的特性、调节及其在各种形式心脏病发展中的作用。本文简要综述了TRPC通道在心肌功能调节中的作用，以及TRPC通道如何作为心力衰竭和包括心房颤动在内的心律失常的治疗靶点。
