Ambudkar Indu S
Secretory Physiology Section, GTTB, National Institute of Dental and Craniofacial Research/NIH, Bethesda, MD 20892, USA.
Trends Pharmacol Sci. 2006 Jan;27(1):25-32. doi: 10.1016/j.tips.2005.11.008. Epub 2005 Dec 7.
The transient receptor potential canonical family (TRPC1-TRPC7) of ion channel proteins, which are activated in response to agonist-stimulated phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P(2)] hydrolysis, are proposed components of the elusive store-operated Ca(2+) (SOC) channel. TRPC channels display distinct properties and interact to form homomeric or heteromeric channels that differ in their function and regulation. Although the exact function of TRPC channels and how they are regulated has not been established, increasing data suggest that they are localized and regulated within Ca(2+) signaling microdomains. TRPC channels contribute to store-operated and store-independent Ca(2+) entry mechanisms, both of which are activated by agonist-stimulated PtdIns(4,5)P(2) hydrolysis. Elucidation of how cells achieve specificity and precise temporal and spatial coordination of channel activation is crucial for understanding the molecular basis of agonist-mediated stimulation of Ca(2+) entry and identifying downstream physiological functions. This review will address the assembly and localization of TRPC channels and how these processes impact their function.
瞬时受体电位香草酸亚家族（TRPC1 - TRPC7）离子通道蛋白可响应激动剂刺激的磷脂酰肌醇（4,5）-二磷酸[PtdIns(4,5)P(2)]水解而被激活，被认为是难以捉摸的储存性钙（Ca(2+)）通道（SOC）的组成成分。TRPC通道具有不同特性，并相互作用形成同聚体或异聚体通道，其功能和调节方式各异。尽管TRPC通道的确切功能及其调节方式尚未明确，但越来越多的数据表明它们定位于钙（Ca(2+)）信号微区并在其中受到调节。TRPC通道参与储存性和非储存依赖性钙（Ca(2+)）内流机制，这两种机制均由激动剂刺激的PtdIns(4,5)P(2)水解激活。阐明细胞如何实现通道激活的特异性以及精确的时间和空间协调，对于理解激动剂介导的钙（Ca(2+)）内流刺激的分子基础以及确定下游生理功能至关重要。本综述将探讨TRPC通道的组装和定位以及这些过程如何影响其功能。
