Costa Tânia D F, Strömblad Staffan
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Mol Cell Oncol. 2020 Jan 20;7(2):1684129. doi: 10.1080/23723556.2019.1684129. eCollection 2020.
Normal cells exposed to cancer-causing events respond by triggering cellular senescence, a stress response which halts cell proliferation and constitutes a protective anti-cancer barrier. We have uncovered a previously unknown signaling pathway implicating p21-activated kinase 4 (PAK4) in the control of senescence in breast cancer, via the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit RELB and the CCAAT-enhancer-binding protein beta (C/EBPβ).
暴露于致癌事件的正常细胞会通过触发细胞衰老做出反应，细胞衰老是一种应激反应，它会停止细胞增殖并构成一道保护性抗癌屏障。我们发现了一条此前未知的信号通路，该通路涉及p21激活激酶4（PAK4）通过活化B细胞核因子κB轻链增强子（NF-κB）亚基RELB和CCAAT增强子结合蛋白β（C/EBPβ）来控制乳腺癌中的细胞衰老。
