Bueno Maria J, Quintela-Fandino Miguel
Breast Cancer Clinical Research Unit, CNIO-Spanish National Cancer Research Center, Madrid, Spain.
Medical Oncology, Hospital Universitario Quiron, Pozuelo de Alarcon, Madrid, Spain.
Mol Cell Oncol. 2020 Jan 20;7(2):1709389. doi: 10.1080/23723556.2019.1709389. eCollection 2020.
Targeting metabolic reprogramming has emerged as a promising strategy for therapeutic intervention in cancer. We identify that fatty acid synthase (FASN) is essential for cancer initiation playing a critical role in acquiring three-dimensional (3D) growth properties during transformation. inhibition of FASN before oncogenic activation prevents tumor development and invasive growth suggesting that FASN could be a potential target for cancer prevention.
靶向代谢重编程已成为癌症治疗干预的一种有前景的策略。我们发现脂肪酸合酶（FASN）对于癌症起始至关重要，在细胞转化过程中获得三维（3D）生长特性方面发挥着关键作用。在致癌激活之前抑制FASN可预防肿瘤发展和侵袭性生长，这表明FASN可能是癌症预防的一个潜在靶点。
