De Giovanni N, Chiarotti M
Istituto di Medicina Legale e delle Assicurazioni, Università Cattolica del Sacro Cuore, Rome, Italy.
J Chromatogr. 1988 Jul 15;428(2):321-9.
A molecular rearrangement of benzophenones (hydrolysis products of 1,4-benzodiazepines) to 9-acridones has been studied. The compounds synthesized were analysed by high-performance liquid chromatography coupled with a fluorescence detector, because of their high luminescence. The method, which can detect sixteen benzodiazepines simultaneously, is highly sensitive and adequately specific. It is reliable for the analysis of these compounds in biological samples at therapeutic concentrations.
已对二苯甲酮（1,4-苯二氮䓬的水解产物）向9-吖啶酮的分子重排进行了研究。由于合成的化合物具有高发光性，因此通过与荧光检测器联用的高效液相色谱法对其进行分析。该方法可同时检测16种苯二氮䓬，具有高灵敏度和足够的特异性。它对于分析治疗浓度下生物样品中的这些化合物是可靠的。
