利用磷脂纳米盘和溶液态 NMR 技术组合阐明磷脂双层与小分子的相互作用。
The elucidation of phospholipid bilayer-small molecule interactions using a combination of phospholipid nanodiscs and solution state NMR techniques.
机构信息
School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK.
出版信息
Chem Commun (Camb). 2020 Apr 11;56(28):4015-4018. doi: 10.1039/c9cc09948d. Epub 2020 Mar 11.
PMID:32159532
Abstract
Quantifying phospholipid bilayer-small molecule interactions is vital to the development of new drug candidates and/or medicinal therapies. However, obtaining these data remains problematic. Herein, we detail a phospholipid nanodisc assay which enables the elucidation of these interactions using conventional solution state NMR spectroscopy techniques.
摘要
定量研究磷脂双层-小分子相互作用对于开发新的药物候选物和/或药物疗法至关重要。然而，获得这些数据仍然存在问题。在此，我们详细介绍了一种磷脂纳米盘测定法，该方法可利用常规的溶液核磁共振波谱技术阐明这些相互作用。
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