Chalisova N I, Rizhak G A, Zayitseva M A, Alexandrova M L, Krasnova A A, Khalaman V V, Kozina L S
I.P.Pavlov Institute of Physiology RAS, 6 nab. Makarova, St. Petersburg 199034, Russian Federation, e-mail:
Saint-Petersburg Institute of Bioregulation and Gerontology, 3 pr. Dinamo, St. Petersburg 197110, Russian Federation, e-mail:
Adv Gerontol. 2019;32(6):990-995.
The influence of water-soluble fraction F-55 of brown algae extract Fucus vesiculosus on the development of organotypic tissue culture of different genesis, originating from three germ leaves in young and old rats was studied. The preparation F-55 has a stimulating effect on the processes of cell proliferation in the tissues of ecto-, ento- and mesodermal genesis (cerebral cortex, myocardium, spleen and liver), by regulating the processes of cell proliferation and apoptosis. The revealed strengthening of regeneration processes in explants from both young and old rats under the influence of F-55 preparation in the range of ultra-low concentrations of 10-100 ng/ml can serve as a basis for the creation of new medicinal cytoprotective substances that allow to enhance cell regeneration in various tissues in pathological conditions, including those associated with age.
