Wei Qi, Huang Linxiang, Li Jie, Chen Bingzhi, Xie Baogui, Teng Hui, Chen Lei, Jiang Yuji
College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, China.
Mycological Research Center, Fujian Agriculture and Forestry University, Fuzhou, China.
J Food Biochem. 2020 May;44(5):e13170. doi: 10.1111/jfbc.13170. Epub 2020 Mar 11.
Agaricus blazei Murrill (ABM), is a medicinal mushroom, has beneficial effects on diabetes mellitus. In this study, ABM extracts (ethanol extract, EE and ethyl acetate extract, EA) were evaluated to explore the beneficial effect on hepatic antioxidant activity and recovery of the pancreatic tissue in streptozotocin-induced diabetic rats. The hepatic antioxidant activities of ABM extracts were analyzed by superoxide dismutase, catalase activity, glutathione, aspartate transaminase, and alanine transaminase. Moreover, the effects of ABM extracts on pancreatic tissue restoration were investigated by histopathological analysis. The results revealed that the EA showed a better protective effect on hepatic antioxidant activity and recovery of the impaired pancreatic tissues, compared to EE. The results suggested that ABM treatment could effectively reduce oxidative stress and contribute to pancreatic tissue recovery. Therefore, ABM could be used as a functional food to control diabetes. PRACTICAL APPLICATIONS: The research may contribute to the development of ABM as functional foods or dietary supplements for diabetes in the future.
姬松茸是一种药用蘑菇，对糖尿病有有益作用。在本研究中，对姬松茸提取物（乙醇提取物，EE和乙酸乙酯提取物，EA）进行评估，以探讨其对链脲佐菌素诱导的糖尿病大鼠肝脏抗氧化活性和胰腺组织恢复的有益作用。通过超氧化物歧化酶、过氧化氢酶活性、谷胱甘肽、天冬氨酸转氨酶和丙氨酸转氨酶分析姬松茸提取物的肝脏抗氧化活性。此外，通过组织病理学分析研究姬松茸提取物对胰腺组织恢复的影响。结果显示，与EE相比，EA对肝脏抗氧化活性和受损胰腺组织的恢复具有更好的保护作用。结果表明，姬松茸处理可有效降低氧化应激并有助于胰腺组织恢复。因此，姬松茸可用作控制糖尿病的功能性食品。实际应用：该研究可能有助于未来将姬松茸开发为糖尿病的功能性食品或膳食补充剂。
