Jian Wen, Wei Chun-Mei, Guan Jia-Hui, Mo Chang-Hua, Xu Yu-Tao, Zheng Wen-Bo, Li Lang, Gui Chun
Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, 06 Shuangyong Road, Nanning, 530021, Guangxi, People's Republic of China.
Guangxi Key Laboratory Base of Precision Medicine in Cardio-Cerebrovascular Diseases Control and Prevention, Nanning, 530021, Guangxi, People's Republic of China.
J Transl Med. 2020 Mar 11;18(1):124. doi: 10.1186/s12967-020-02292-1.
Research has associated human epidermal growth factor receptor (HER2) with glucose and lipid metabolism. However, the association between circulating HER2 levels and coronary artery disease (CAD) remains to be elucidated.
We performed a case-control study with 435 participants (237 CAD patients and 198 controls) who underwent diagnostic coronary angiography from September 2018 to October 2019. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for CAD were calculated with multiple logistic regression models after adjustment for confounders.
Overall, increased serum HER2 levels were independently associated with the presence of CAD (OR per 1-standard deviation (SD) increase: 1.438, 95% CI 1.13-1.83; P = 0.003) and the number of stenotic vessels (OR per 1-SD increase: 1.399, 95% CI 1.15-1.71; P = 0.001). In the subgroup analysis, a significant interaction of HER2 with body mass index (BMI) on the presence of CAD was observed (adjusted interaction P = 0.046). Increased serum HER2 levels were strongly associated with the presence of CAD in participants with BMI ≥ 25 kg/m (OR per 1-SD increase: 2.143, 95% CI 1.37-3.35; P = 0.001), whereas no significant association was found in participants with BMI < 25 kg/m (OR per 1-SD increase: 1.225, 95% CI 0.90-1.67; P = 0.201).
Elevated HER2 level is associated with an increased risk of CAD, particularly in people with obesity. This finding yields new insight into the pathological mechanisms underlying CAD, and warrants further research regarding HER2 as a preventive and therapeutic target of CAD.
研究已将人类表皮生长因子受体（HER2）与葡萄糖和脂质代谢联系起来。然而，循环HER2水平与冠状动脉疾病（CAD）之间的关联仍有待阐明。
我们进行了一项病例对照研究，纳入了435名参与者（237例CAD患者和198名对照），这些参与者于2018年9月至2019年10月接受了诊断性冠状动脉造影。在对混杂因素进行调整后，使用多元逻辑回归模型计算CAD的调整比值比（OR）和95%置信区间（CI）。
总体而言，血清HER2水平升高与CAD的存在独立相关（每增加1个标准差（SD）的OR：1.438，95%CI 1.13 - 1.83；P = 0.003）以及狭窄血管数量相关（每增加1个SD的OR：1.399，95%CI 1.15 - 1.71；P = 0.001）。在亚组分析中，观察到HER2与体重指数（BMI）在CAD存在方面存在显著交互作用（调整后的交互作用P = 0.046）。血清HER2水平升高与BMI≥25 kg/m²的参与者中CAD的存在密切相关（每增加1个SD的OR：2.143，95%CI 1.37 - 3.35；P = 0.001），而在BMI<25 kg/m²的参与者中未发现显著关联（每增加1个SD的OR：1.225，95%CI 0.90 - 1.67；P = 0.201）。
HER2水平升高与CAD风险增加相关，尤其是在肥胖人群中。这一发现为CAD潜在的病理机制提供了新的见解，并值得进一步研究将HER2作为CAD的预防和治疗靶点。
