孕期运动引起的静息状态下母体生理变化：一项随机对照试验。

Maternal physiological changes at rest induced by exercise during pregnancy: A randomized controlled trial.

作者信息

Fernández-Buhigas Irene, Brik Maia, Martin-Arias Aranzazu, Vargas-Terrones Marina, Varillas David, Barakat Rubén, Santacruz Belén

机构信息

Obstetrics Department, Hospital Universitario de Torrejon, Madrid, Spain; Faculty of Medicine, Pozuelo de Alarcón, Universidad Francisco de Vitoria, Madrid, Spain.

Obstetrics Department, Hospital Universitario de Torrejon, Madrid, Spain; Faculty of Medicine, Pozuelo de Alarcón, Universidad Francisco de Vitoria, Madrid, Spain; Maternal Fetal Medicine Department. Hospital Universitari Vall d'Hebron. Universitat Autonoma de Barcelona. Barcelona, Spain.

出版信息

Physiol Behav. 2020 Jun 1;220:112863. doi: 10.1016/j.physbeh.2020.112863. Epub 2020 Mar 8.

DOI:10.1016/j.physbeh.2020.112863

PMID:32160968

Abstract

OBJECTIVE

to analyse maternal physiological changes in several areas (cardiovascular, metabolic, renal and hepatic) related to the regular practice of a supervised exercise program.

METHODS

This is an unplanned secondary analysis from a randomized controlled trial carried out in a single maternity unit in Madrid, Spain (NCT 02,756,143). From November 2014 to June 2015, 92 women were randomly assigned to perform a mild-moderate supervised exercise program during pregnancy (Intervention group, IG) or to continue with their routine pregnancy care (control group, CG). For the purpose of this study we collected clinical and analytical data (heart blood pressure, weight, blood glucose, AST, ALT, blood Creatinine and blood Uric acid) available from all obstetric visits and examined the differences between groups.

RESULTS

We did not find any differences in: pregnancy weight (IG: 11.4 ± 4.4 Kg vs. CG: 10.1 ± 5.3 Kg; p = 0.173); fasting glucose at 10-12 weeks (IG: 78.48±8.34 vs. CG: 76±13.26, p = 0.305) or at 34-36 weeks (IG: 73.25±10.27 vs CG: 73.45± 8.29,p = 0.920), and 50 gs glucose tolerance at 24-26weeks (IG: 116.23±35.07 vs CG: 116.36±25.98, p = 0.984); Aspartate-amino-transferase at 10-12 weeks (IG: 15.38±4.17 vs CG: 17.33±7.05, p = 0.124) and at 34-36 weeks (IG: 21.65±5.25 vs CG: 19.53±8.32, p = 0.165) or Alanine-amino- transferase at 10-12 weeks (IG: 27.50±10.63 vs CG: 28.27±11.77, p = 0.746) or at 34-36 weeks (IG: 22.93±9.23 vs CG: 20.84±13.49, p = 0.407); blood Creatinine concentrations at 34-36 weeks (IG: 0.595±0.401 vs CG: 0.575±0.100, p = 0.757) and blood uric acid concentrations at 34-36 weeks (IG: 3.526 ± 0.787 vs CG: 3.262±0.672, p = 0.218). Heart blood pressure was similar between groups except at 27-28 weeks, where systolic blood pressure was significantly lower in the CG in comparison to the IG (116.31±10.8 mmHg vs. 120.22 ± 10.3 mmHg, p = 0.010).

CONCLUSION

Regular supervised exercise during pregnancy does not alter normal maternal physiology.

摘要

目的

分析与有监督的运动计划常规实施相关的几个领域（心血管、代谢、肾脏和肝脏）的母体生理变化。

方法

这是一项对在西班牙马德里的一个单一产科病房进行的随机对照试验的非计划二次分析（NCT 02,756,143）。从2014年11月至2015年6月，92名女性被随机分配在孕期进行轻度至中度的有监督运动计划（干预组，IG）或继续进行常规孕期护理（对照组，CG）。为了本研究的目的，我们收集了所有产科检查中可用的临床和分析数据（心脏血压、体重、血糖、AST、ALT、血肌酐和血尿酸），并检查了组间差异。

结果

我们未发现以下方面存在差异：孕期体重（IG：11.4±4.4千克 vs. CG：10.1±5.3千克；p = 0.173）；10 - 12周时的空腹血糖（IG：78.48±8.34 vs. CG：76±13.26，p = 0.305）或34 - 36周时的空腹血糖（IG：73.25±10.27 vs CG：73.45±8.29，p = 0.920），以及24 - 26周时的50克葡萄糖耐量（IG：116.23±35.07 vs CG：116.36±25.98，p = 0.984）；10 - 12周时的天冬氨酸氨基转移酶（IG：15.38±4.17 vs CG：17.33±7.05，p = 0.124）和34 - 36周时的天冬氨酸氨基转移酶（IG：21.65±5.25 vs CG：19.53±8.32，p = 0.165）或10 - 12周时的丙氨酸氨基转移酶（IG：27.50±10.63 vs CG：28.27±11.77，p = 0.746）或34 - 36周时的丙氨酸氨基转移酶（IG：22.93±9.23 vs CG：20.84±13.49，p = 0.407）；34 - 36周时的血肌酐浓度（IG：0.595±0.401 vs CG：0.575±0.100，p = 0.757）和34 - 36周时的血尿酸浓度（IG：3.526±0.787 vs CG：3.262±0.672，p = 0.218）。除了在27 - 28周时，两组间的心脏血压相似，此时与IG相比，CG的收缩压显著更低（116.31±10.8毫米汞柱 vs. 120.22±10.3毫米汞柱，p = 0.010）。