Wei Juanbing, Lin Jing
Department of Obstetrics and Gynecology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China
Department of Obstetrics and Gynecology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Ann Clin Lab Sci. 2020 Jan;50(1):79-84.
To investigate the relationship of polymorphism in vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) with preeclampsia (PE).
The present study included 252 patients with PE and 200 healthy pregnant women as control admitted to our hospital from February 2012 to December 2016. Allelic discrimination of the rs5498 polymorphisms from the ICAM-1 gene and rs3181092 from the VCAM-1 gene was assessed using the TaqMan assay. Data was analyzed using SPSS 18.0.
In PE patients, both ratios of AA and AA+AG genotypes of VCAM-1 were significantly higher than those in the control group, <0.05. The comparison of genotypes between PE patients with early-onset and late-onset showed that late-onset PE patients had a higher ratio of AA genotype in VCAM-1, <0.05. Similarly, the ratio of genotype AA in severe PE was significantly higher than that in mild PE patients, <0.05. However, the distribution of rs5498 polymorphism for ICAM-1 showed no significant difference in the groups.
Rs3181092 polymorphism of VCAM-1 was associated with occurrence of PE, especially for late-onset and severe PE. However, whether rs5498 polymorphism of ICAM-1was associated with PE needs more investigation.
探讨血管细胞黏附分子-1（VCAM-1）和细胞间黏附分子-1（ICAM-1）基因多态性与子痫前期（PE）的关系。
本研究纳入2012年2月至2016年12月在我院收治的252例PE患者及200例健康孕妇作为对照。采用TaqMan法对ICAM-1基因的rs5498多态性和VCAM-1基因的rs3181092进行等位基因鉴别。数据采用SPSS 18.0软件进行分析。
PE患者中，VCAM-1基因AA和AA+AG基因型比例均显著高于对照组，P<0.05。早发型和晚发型PE患者基因型比较显示晚发型PE患者VCAM-1基因AA基因型比例更高，P<0.05。同样，重度PE患者基因型AA比例显著高于轻度PE患者，P<0.05。然而，ICAM-1基因rs5498多态性在各组间分布无显著差异。
VCAM-1基因rs3181092多态性与PE的发生有关，尤其是晚发型和重度PE。然而，ICAM-1基因rs5498多态性是否与PE有关尚需更多研究。
