Department of Cerebrovascular Diseases, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China.
J Clin Microbiol. 2020 Apr 23;58(5). doi: 10.1128/JCM.00187-20.
The new decade of the 21 century (2020) started with the emergence of a novel coronavirus known as SARS-CoV-2 that caused an epidemic of coronavirus disease (COVID-19) in Wuhan, China. It is the third highly pathogenic and transmissible coronavirus after severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in humans. The source of origin, transmission to humans, and mechanisms associated with the pathogenicity of SARS-CoV-2 are not yet clear, however, its resemblance to SARS-CoV and several other bat coronaviruses was recently confirmed through genome sequencing-related studies. The development of therapeutic strategies is necessary in order to prevent further epidemics and cure infections. In this review, we summarize current information about the emergence, origin, diversity, and epidemiology of three pathogenic coronaviruses with a specific focus on the current outbreak in Wuhan, China. Furthermore, we discuss the clinical features and potential therapeutic options that may be effective against SARS-CoV-2.
21 世纪的新十年（2020 年）伊始，一种新型冠状病毒（SARS-CoV-2）出现，导致中国武汉爆发冠状病毒病（COVID-19）疫情。这是继严重急性呼吸综合征冠状病毒（SARS-CoV）和中东呼吸综合征冠状病毒（MERS-CoV）之后，人类感染的第三种高致病性和高传染性冠状病毒。SARS-CoV-2 的起源、传播给人类的途径以及与致病性相关的机制尚不清楚，然而，通过与基因组测序相关的研究，最近证实了其与 SARS-CoV 以及其他几种蝙蝠冠状病毒的相似性。为了防止进一步的疫情爆发和治疗感染，有必要开发治疗策略。在这篇综述中，我们总结了三种致病性冠状病毒的出现、起源、多样性和流行病学的最新信息，特别关注中国武汉目前的疫情。此外，我们还讨论了可能对 SARS-CoV-2 有效的临床特征和潜在治疗选择。
