高尿酸血症是老年女性急性冠状动脉综合征患者一年总生存率的危险因素。
Hyperuricemia is a Risk Factor for One-Year Overall Survival in Elderly Female Patients with Acute Coronary Syndrome.
机构信息
Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China.
出版信息
Cardiovasc Ther. 2020 Feb 22;2020:2615147. doi: 10.1155/2020/2615147. eCollection 2020.
BACKGROUND
Hyperuricemia is a risk factor for cardiovascular diseases, but the impact of hyperuricemia and sex-related disparities is not fully clear in elderly patients with acute coronary syndrome (ACS).
OBJECTIVE
To investigate the association between hyperuricemia and 1-year all-cause mortality in elderly patients with ACS.
METHODS
This retrospective cohort study included 711 consecutive ACS patients aged ≥75 years, hospitalized in our center between January 2013 and December 2017. Serum uric acid (sUA), in-hospital events, and 1-year follow-up were analyzed. Multivariable logistic regression models were used to explore the risk factors for in-hospital events and 1-year all-cause mortality.
RESULTS
sUA levels were higher in males than in females (381.4 ± 110.1 vs. 349.3 ± 119.1 mol/l, < 0.001). Prevalence of hypertension (80.5% vs. 72.6%, < 0.001). Prevalence of hypertension (80.5% vs. 72.6%, < 0.001). Prevalence of hypertension (80.5% vs. 72.6%, < 0.001). Prevalence of hypertension (80.5% vs. 72.6%, < 0.001). Prevalence of hypertension (80.5% vs. 72.6%, < 0.001). Prevalence of hypertension (80.5% vs. 72.6%, < 0.001). Prevalence of hypertension (80.5% vs. 72.6%, < 0.001). Prevalence of hypertension (80.5% vs. 72.6%, < 0.001). Prevalence of hypertension (80.5% vs. 72.6%.
CONCLUSIONS
Hyperuricemia is an independent risk factor for 1-year all-cause mortality in elderly female patients with ACS.
背景
高尿酸血症是心血管疾病的危险因素，但在老年急性冠状动脉综合征（ACS）患者中，高尿酸血症与性别相关差异的影响尚不完全清楚。
目的
探讨高尿酸血症与老年 ACS 患者 1 年全因死亡率的关系。
方法
本回顾性队列研究纳入了 2013 年 1 月至 2017 年 12 月期间在我院住院的 711 例年龄≥75 岁的 ACS 患者。分析血清尿酸（sUA）、住院期间事件及 1 年随访情况。采用多变量 logistic 回归模型探讨住院期间事件及 1 年全因死亡率的危险因素。
结果
男性 sUA 水平高于女性（381.4±110.1 比 349.3±119.1 μmol/L，<0.001）。男性高血压患病率（80.5%比 72.6%，<0.001）、心力衰竭患病率（17.5%比 11.7%，<0.001）、既往心肌梗死患病率（18.2%比 12.5%，<0.001）均高于女性。多变量 logistic 回归分析显示，在校正了年龄、性别、高血压、心力衰竭、既往心肌梗死、hs-CRP、估算肾小球滤过率（eGFR）、左心室射血分数（LVEF）后，高尿酸血症与女性 ACS 患者 1 年全因死亡率相关（OR=1.444，95%CI：1.021～2.045，P=0.037）。
结论
高尿酸血症是老年女性 ACS 患者 1 年全因死亡率的独立危险因素。
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