Rubel P, Fayn J, Mohsen N, Girard P
Institut National des Sciences Appliquées Département Informatique, Villeurbanne, France.
J Electrocardiol. 1988;21 Suppl:S177-81. doi: 10.1016/0022-0736(88)90089-1.
The authors present a method for optimally measuring variations in T wave shape and time intervals for the quantitative assessment of the significance of serial changes of the repolarization phase. The results, established on a healthy population, show the inadequacy of Bazett's formula, the constancy of maximum of T to the end of the T time interval, and good stability of the spatial T loops' morphotype. Residual intrasubject variability of corrected QT interval is mainly ascribable to physiologic, heart rate-independent changes in true onset of Q to a maximum of T time interval. The optimized mean quadratic deviation between two serial T loops is well correlated with changes in drug concentration.
作者提出了一种用于最佳测量T波形态和时间间隔变化的方法，以定量评估复极相系列变化的意义。基于健康人群得出的结果显示，巴泽特公式并不适用，T波峰值至T波时间间隔终点的恒定，以及空间T环形态型的良好稳定性。校正QT间期的残余个体内变异性主要归因于Q波起始至T波峰值时间间隔的真实起始的生理、心率无关变化。两个连续T环之间优化的均方偏差与药物浓度变化密切相关。
