Lindblad R M, Lassila L V J, Vallittu P K, Tjäderhane L
Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.
Department of Biomaterials Science and Turku Clinical Biomaterials Centre-TCBC, Institute of Dentistry, University of Turku, Turku, Finland.
Eur Endod J. 2019 Feb 5;4(1):38-44. doi: 10.14744/eej.2018.02886. eCollection 2019.
The aim of root canal obturation is to prevent leakage and inhibit microbial invasion. This study aimed to determine the effect of chlorhexidine (CHX) and dimethyl sulfoxide (DMSO) as final irrigants on microleakage of root filling immediately and after 18 months. The hypothesis was that either CHX or DMSO would not affect the immediate or long-term microleakage.
A total of 120 human third molar root canals were obturated with RealSeal SE or Topseal and gutta percha. Before obturation, the canals were irrigated with saline (control), 2% CHX or 5% DMSO. Microleakage of half of each groups (n=10) was measured after 3 days, and of the other half was measured after 18 months with fluid filtration method.
In immediate measurements, RealSeal SE performed significantly better in CHX-irrigated group (p=0.035; Mann-Whitney test). For both sealers, DMSO had the lowest mean microleakage values, which were also statistically significantly lower than with CHX irrigation within sealers (p<0.009 for Topseal and p=0.04 for RealSeal SE; Mann-Whitney test). With RealSeal SE, the microleakage with CHX was significantly higher than that in controls (p=0.022; Mann-Whitney test).
Neither final irrigant showed statistically significant differences in the immediate microleakage within the two sealers. Irrigation with DMSO caused significantly less microleakage than CHX for both sealers after 18 months.
根管充填的目的是防止渗漏并抑制微生物侵入。本研究旨在确定洗必泰（CHX）和二甲基亚砜（DMSO）作为最终冲洗剂对根管充填即刻及18个月后的微渗漏的影响。假设是CHX或DMSO均不会影响即刻或长期的微渗漏。
总共120颗人第三磨牙根管采用RealSeal SE或Topseal及牙胶进行充填。在充填前，根管用生理盐水（对照）、2% CHX或5% DMSO冲洗。每组一半（n = 10）在3天后用液体过滤法测量微渗漏，另一半在18个月后测量。
在即刻测量中，RealSeal SE在CHX冲洗组中表现明显更好（p = 0.035；Mann-Whitney检验）。对于两种封闭剂，DMSO的平均微渗漏值最低，在封闭剂中也显著低于CHX冲洗组（Topseal的p < 0.009，RealSeal SE的p = 0.04；Mann-Whitney检验）。使用RealSeal SE时，CHX组的微渗漏显著高于对照组（p = 0.022；Mann-Whitney检验）。
两种最终冲洗剂在两种封闭剂的即刻微渗漏方面均未显示出统计学上的显著差异。18个月后，对于两种封闭剂，用DMSO冲洗引起的微渗漏明显少于CHX冲洗。
