Division of Implantology and Periodontology, Department of Highly Advanced Stomatology, Graduate School of Dentistry, Kanagawa Dental University, 3-31-6, Kanagawa-ku, Yokohama, Kanagawa, 221-0835, Japan.
Odontology. 2020 Oct;108(4):578-587. doi: 10.1007/s10266-020-00506-y. Epub 2020 Mar 11.
After tooth extraction, the alveolar ridge is absorbed and changes shape. Recently, socket preservation has been proposed to prevent alveolar ridge absorption. However, there are few reports of socket preservation in a model without the periosteum, and alveolar bone regeneration and resorption inhibitory effects in this type of model remain unclear. Therefore, in this study, we conducted socket preservation at the bone defect without the periosteum using a canine model. Ten beagle dogs were extracted. A 5 mm × 7 mm × 4 mm bone defect was created without the periosteum. Defects were filled with beta-tricalcium phosphate (β-TCP)/collagen (Col), β-TCP, collagen, or left intact (Control). The observation periods were 4 and 8 weeks (n = 5 per group). Evaluations were made of the newly formed bone area, residual granular area, horizontal width and vertical dimensional change. The newly formed bone area at 4 weeks after surgery in TCP/Col, Collagen, β-TCP, and Control groups was 21.50%, 17.26%, 18.22%, and 17.47%. Compared to the control group, the TCP/Col group showed a significant difference in bone regeneration and horizontal width. TCP/Col is suggested to be effective for bone regeneration and suppression of alveolar ridge resorption in the bone defect periosteum removal model.
拔牙后，牙槽嵴会吸收并改变形状。最近，提出了牙槽窝保存以防止牙槽嵴吸收。然而，在没有骨膜的模型中，关于牙槽窝保存的报道很少，并且这种类型的模型中的牙槽骨再生和吸收抑制作用尚不清楚。因此，在这项研究中，我们使用犬模型在没有骨膜的骨缺损部位进行了牙槽窝保存。将 10 只比格犬拔牙。在没有骨膜的情况下创建了一个 5×7×4mm 的骨缺损。用β-磷酸三钙(β-TCP)/胶原(Col)、β-TCP、胶原或不填充（对照）来填充缺损。观察期为 4 和 8 周（每组 n=5）。评估新形成的骨区、残留颗粒区、水平宽度和垂直尺寸变化。术后 4 周，TCP/Col、胶原、β-TCP 和对照组的新形成骨区分别为 21.50%、17.26%、18.22%和 17.47%。与对照组相比，TCP/Col 组的骨再生和水平宽度有显著差异。TCP/Col 被认为在骨膜去除模型的骨缺损中对于骨再生和抑制牙槽嵴吸收是有效的。
