Inchingolo Francesco, Hazballa Denisa, Inchingolo Alessio Danilo, Malcangi Giuseppina, Marinelli Grazia, Mancini Antonio, Maggiore Maria Elena, Bordea Ioana Roxana, Scarano Antonio, Farronato Marco, Tartaglia Gianluca Martino, Lorusso Felice, Inchingolo Angelo Michele, Dipalma Gianna
Department of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
Kongresi Elbasanit, Rruga: Aqif Pasha, 3001 Elbasan, Albania.
Materials (Basel). 2022 Jan 31;15(3):1120. doi: 10.3390/ma15031120.
For decades, regenerative medicine and dentistry have been improved with new therapies and innovative clinical protocols. The aim of the present investigation was to evaluate through a critical review the recent innovations in the field of bone regeneration with a focus on the healing potentials and clinical protocols of bone substitutes combined with engineered constructs, growth factors and photobiomodulation applications.
A Boolean systematic search was conducted by PubMed/Medline, PubMed/Central, Web of Science and Google scholar databases according to the PRISMA guidelines.
After the initial screening, a total of 304 papers were considered eligible for the qualitative synthesis. The articles included were categorized according to the main topics: alloplastic bone substitutes, autologous teeth derived substitutes, xenografts, platelet-derived concentrates, laser therapy, microbiota and bone metabolism and mesenchymal cells construct.
The effectiveness of the present investigation showed that the use of biocompatible and bio-resorbable bone substitutes are related to the high-predictability of the bone regeneration protocols, while the oral microbiota and systemic health of the patient produce a clinical advantage for the long-term success of the regeneration procedures and implant-supported restorations. The use of growth factors is able to reduce the co-morbidity of the regenerative procedure ameliorating the post-operative healing phase. The LLLT is an adjuvant protocol to improve the soft and hard tissues response for bone regeneration treatment protocols.
几十年来，再生医学和牙科领域通过新疗法和创新临床方案不断发展。本研究的目的是通过批判性综述评估骨再生领域的最新创新，重点关注骨替代物与工程构建体、生长因子及光生物调节应用相结合的愈合潜力和临床方案。
根据PRISMA指南，通过PubMed/Medline、PubMed/Central、科学网和谷歌学术数据库进行布尔系统检索。
初步筛选后，共304篇论文被认为符合定性综合分析的条件。纳入的文章根据主要主题分类：异体骨替代物、自体牙衍生替代物、异种移植物、血小板衍生浓缩物、激光治疗、微生物群与骨代谢以及间充质细胞构建体。
本研究的有效性表明，使用生物相容性和生物可吸收性骨替代物与骨再生方案的高可预测性相关，而患者的口腔微生物群和全身健康状况为再生程序和种植体支持修复的长期成功带来临床优势。生长因子的使用能够降低再生程序的合并症，改善术后愈合阶段。低强度激光治疗是一种辅助方案，可改善骨再生治疗方案中软组织和硬组织反应。
