评估柠檬酸镁和氧化镁中镁的生物利用度，通过测量镁饱和受试者的尿排泄量。

Assessment of bioavailability of Mg from Mg citrate and Mg oxide by measuring urinary excretion in Mg-saturated subjects.

机构信息

NuOmix Research k.s. Applied Nutriomic Research, MartinSlovakia.

NuOmix Research k.s. Applied Nutriomic Research, MartinSlovakia, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Biomedical Center Martin, Division of Neurosciences, MartinSlovakia.

出版信息

Magnes Res. 2019 Aug 1;32(3):63-71. doi: 10.1684/mrh.2019.0457.

DOI:10.1684/mrh.2019.0457

PMID:32162607

Abstract

BACKGROUND

Low magnesium (Mg) levels are linked to many diseases. Studies suggest that organic salts of Mg are more readily bioavailable than its oxide or inorganic salts used for supplements production. Unfortunately, the plethora of variables in the previous study designs complicates the making of any clear and reliable conclusions.

METHODS

14 healthy males were supplemented for five days with 400 mg Mg to saturate Mg pools before intake of the test products. Bioavailability of 400 mg Mg from Mg citrate (MgC) and Mg oxide (MgO) after single-dose administration was assessed by measuring renal Mg excretion in 24-h urine and blood plasma [Mg] at time points 0, 2, 4, 8, and 24 h.

RESULTS

Single-dose MgC supplementation led to a significant (P < 0.05) increase in 24 h urinary Mg excretion, but this was not significant following MgO. Plasma [Mg] was also significantly higher for MgC than for MgO at 4 h (P < 0.05) and 8 h (P < 0.05). Compared with baseline levels, MgC supplementation showed a significant increase in plasma [Mg] at all time points, in contrast to MgO.

CONCLUSIONS

MgC shows higher bioavailability compared with MgO. Furthermore, urinary Mg excretion should be determined as the primary endpoint of Mg bioavailability studies.

摘要

背景

低镁（Mg）水平与许多疾病有关。研究表明，Mg 的有机盐比用于补充剂生产的氧化物或无机盐更易被生物利用。不幸的是，以前的研究设计中的大量变量使得任何明确和可靠的结论都变得复杂。

方法

14 名健康男性在五天内补充 400mg Mg，以使 Mg 池饱和，然后摄入测试产品。通过测量 24 小时尿液中的肾脏 Mg 排泄量和 0、2、4、8 和 24 小时时的血浆 [Mg]，评估单次给予 Mg 柠檬酸盐（MgC）和 Mg 氧化物（MgO）400mg Mg 的生物利用度。

结果

MgC 补充单剂量可显著增加 24 小时尿 Mg 排泄量（P<0.05），但 MgO 补充后则不显著。与 MgO 相比，MgC 也使 4 小时（P<0.05）和 8 小时（P<0.05）的血浆 [Mg] 更高。与基线水平相比，MgC 补充剂在所有时间点均显示出血浆 [Mg] 的显著增加，而 MgO 则没有。