Phenolic glycosides and flavonoids with antioxidant and anticancer activities from .

Descaudatine A (), an undescribed phenolic glycoside, along with a known analogue () and ten flavonoids (), were isolated from the whole plant of . Compounds and exhibited potent antioxidant activities with the IC of 58.59 μM and 31.31 μM, respectively, which were approached to that of the positive control Vitamin C (IC = 46.32 μM). Meanwhile, showed moderate antioxidant activity with the IC of 173.9 μM. Besides, compounds and inhibited the proliferation of HeLa cells with IC values of 56.14 μM and 69.04 μM, respectively. Further studies indicated that and could dose-dependently induce PARP cleavage and might trigger caspase-3, 8, 9 activation to induce apoptosis. RXRα is an ideal anticancer target of nuclear receptor. The reporter gene assay of RXRα indicated that and could inhibited the 9--RA induced RXRα transcription in a concentration-dependent manner.