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时空光学相干(STOC)成像中的计算像差校正。

Computational aberration correction in spatiotemporal optical coherence (STOC) imaging.

出版信息

Opt Lett. 2020 Mar 15;45(6):1293-1296. doi: 10.1364/OL.384796.

DOI:10.1364/OL.384796
PMID:32163948
Abstract

Spatiotemporal optical coherence (STOC) imaging is a new technique for suppressing coherent cross talk noise in Fourier-domain full-field optical coherence tomography (FD-FF-OCT). In STOC imaging, the time-varying inhomogeneous phase masks modulate the incident light to alter the interferometric signal. Resulting interference images are then processed as in standard FD-FF-OCT and averaged incoherently or coherently to produce cross-talk-free volumetric optical coherence tomography (OCT) images of the sample. Here, we show that coherent averaging is suitable when phase modulation is performed for both interferometer arms simultaneously. We explain the advantages of coherent over incoherent averaging. Specifically, we show that modulated signal, after coherent averaging, preserves lateral phase stability, enabling computational phase correction to compensate for geometrical aberrations. Ultimately, we employ it to correct for aberrations present in the image of the photoreceptor layer of the human retina that reveals otherwise invisible photoreceptor mosaics.

摘要

时空域光学相干(STOC)成像是一种用于抑制傅里叶域全场光学相干断层扫描(FD-FF-OCT)中相干串扰噪声的新技术。在 STOC 成像中,时变非均匀相位掩模调制入射光以改变干涉信号。然后,对所得干涉图像进行与标准 FD-FF-OCT 相同的处理,并以非相干或相干方式进行平均,以产生样品的无串扰容积光学相干断层扫描(OCT)图像。在这里,我们表明当同时对两个干涉臂进行相位调制时,相干平均是合适的。我们解释了相干平均优于非相干平均的优点。具体来说,我们表明,经过相干平均后,调制信号保留了横向相位稳定性,从而可以进行计算相位校正以补偿几何像差。最终,我们将其用于校正人视网膜光感受器层图像中的像差,该图像揭示了否则不可见的光感受器镶嵌。

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