Qiu Shangkun, Zeng Bin
JiangXi Province Key Laboratory of Bioprocess Engineering, College of Life Sciences, Jiangxi Science & Technology Normal University, Nanchang 330013, China.
J Fungi (Basel). 2020 Mar 10;6(1):34. doi: 10.3390/jof6010034.
Acyl-CoA-binding protein (ACBP) is an important protein with a size of about 10 kDa. It has a high binding affinity for C-C acyl-CoA esters and participates in lipid metabolism. ACBP and its family of proteins have been found in all eukaryotes and some prokaryotes. Studies have described the function and structure of ACBP family proteins in mammals (such as humans and mice), plants (such as , , and ) and yeast. However, little information on the structure and function of the proteins in filamentous fungi has been reported. This article concentrates on recent advances in the research of the ACBP family proteins in plants and mammals, especially in yeast, filamentous fungi (such as and ), and fungal pathogens (, ). Furthermore, we discuss some problems in the field, summarize the binding characteristics of the ACBP family proteins in filamentous fungi and yeast, and consider the future of ACBP development.
酰基辅酶A结合蛋白（ACBP）是一种重要的蛋白质，大小约为10 kDa。它对碳链酰基辅酶A酯具有高结合亲和力，并参与脂质代谢。在所有真核生物和一些原核生物中都发现了ACBP及其蛋白家族。已有研究描述了ACBP家族蛋白在哺乳动物（如人类和小鼠）、植物（如 、 、 ）和酵母中的功能与结构。然而，关于丝状真菌中该蛋白的结构和功能的信息报道较少。本文重点关注植物和哺乳动物中ACBP家族蛋白的研究进展，特别是在酵母、丝状真菌（如 、 ）和真菌病原体（ 、 ）中的研究进展。此外，我们讨论了该领域的一些问题，总结了丝状真菌和酵母中ACBP家族蛋白的结合特性，并展望了ACBP的发展前景。
