Raboanatahiry Nadia, Wang Baoshan, Yu Longjiang, Li Maoteng
Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Hubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie Mountains, Huanggang Normal University, Huanggang, China.
Front Genet. 2018 May 22;9:182. doi: 10.3389/fgene.2018.00182. eCollection 2018.
Diversities in structure and function of ACBP were discussed in this review. ACBP are important proteins that could transport newly synthesized fatty acid, activated into -coA, from plastid to endoplasmic reticulum, where oil in the form of triacylglycerol occurs. ACBP were detected in various animal and plants species, which indicated their importance in biological function. In fact, involvement of ACBP in important process such as lipid metabolism, regulation of enzyme and gene expression, and in response to plant stresses has been proven in several studies. In this review, findings on ACBP of 11 well-known oil crops were reviewed to comprehend diversity, comparative analyses on ACBP structure were made, and link between structure and function, tissue expression and subcellular location of ACBP were also observed. Incomplete reports in some species were mentioned, which might be encouraging to start or to perform deeper studies. Similar characteristics were found in paralogs ACBP, and orthologs ACBP had different functions, despite the high identity in amino acid sequence. At the end, it is confirmed that ortholog proteins could not necessarily display the same function, even from closely related species.
本综述讨论了酰基辅酶A结合蛋白（ACBP）在结构和功能上的多样性。ACBP是重要的蛋白质，它能够将新合成的、被激活为酰基辅酶A的脂肪酸从质体转运到内质网，内质网是三酰甘油形式的油脂形成的场所。在各种动植物物种中都检测到了ACBP，这表明它们在生物学功能中具有重要性。事实上，多项研究已证实ACBP参与脂质代谢、酶和基因表达调控以及植物应激反应等重要过程。在本综述中，对11种著名油料作物的ACBP研究结果进行了综述，以了解其多样性，对ACBP结构进行了比较分析，还观察了ACBP的结构与功能、组织表达和亚细胞定位之间的联系。文中提到了一些物种的不完整报告，这可能会鼓励开展或进行更深入的研究。在ACBP旁系同源物中发现了相似的特征，尽管ACBP直系同源物的氨基酸序列具有高度同一性，但它们具有不同的功能。最后证实，即使是来自密切相关物种的直系同源蛋白也不一定具有相同的功能。
