Melnikova Daria N, Finkina Ekaterina I, Bogdanov Ivan V, Tagaev Andrey A, Ovchinnikova Tatiana V
M.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, the Russian Academy of Sciences, Miklukho-Maklaya Str., 16/10, 117997 Moscow, Russia.
Phystech School of Biological and Medical Physics, Moscow Institute of Physics and Technology (State University), 141701 Dolgoprudny, Russia.
Membranes (Basel). 2022 Dec 20;13(1):2. doi: 10.3390/membranes13010002.
In plants, lipid trafficking within and inside the cell is carried out by lipid-binding and transfer proteins. Ligands for these proteins are building and signaling lipid molecules, secondary metabolites with different biological activities due to which they perform diverse functions in plants. Many different classes of such lipid-binding and transfer proteins have been found, but the most common and represented in plants are lipid transfer proteins (LTPs), pathogenesis-related class 10 (PR-10) proteins, acyl-CoA-binding proteins (ACBPs), and puroindolines (PINs). A low degree of amino acid sequence homology but similar spatial structures containing an internal hydrophobic cavity are common features of these classes of proteins. In this review, we summarize the latest known data on the features of these protein classes with particular focus on their ability to bind and transfer lipid ligands. We analyzed the structural features of these proteins, the diversity of their possible ligands, the key amino acids participating in ligand binding, the currently known mechanisms of ligand binding and transferring, as well as prospects for possible application.
在植物中，细胞内和细胞间的脂质运输由脂质结合和转运蛋白完成。这些蛋白的配体是构建和信号脂质分子、具有不同生物活性的次生代谢产物，因此它们在植物中发挥着多种功能。已经发现了许多不同类别的此类脂质结合和转运蛋白，但植物中最常见且具有代表性的是脂质转运蛋白（LTPs）、病程相关蛋白10（PR-10）、酰基辅酶A结合蛋白（ACBPs）和麦醇溶蛋白（PINs）。这些蛋白类别的共同特征是氨基酸序列同源性较低，但具有包含内部疏水腔的相似空间结构。在本综述中，我们总结了关于这些蛋白类别的最新已知数据，特别关注它们结合和转运脂质配体的能力。我们分析了这些蛋白的结构特征、其可能配体的多样性、参与配体结合的关键氨基酸、目前已知的配体结合和转运机制以及可能的应用前景。
