Ichihashi Y, Hori M, Tatsuzawa O, Okabe N, Wakasugi H, Yoshioka H, Fujita K, Sakata H, Ishida C, Kakehashi H
Department of Infectious Disease, National Children's hospital.
Jpn J Antibiot. 1988 May;41(5):538-48.
A multiclinic study of gentamicin (GM) given by intravenous drip infusion was carried out by the Gentamicin Pediatric Study Group. The results are summarized as follows: 1. Upon intravenous drip infusion of GM at a dose range of 2.0-2.5 mg/kg over a period of 0.5-1 hour, therapeutically effective serum concentrations of 4-12 micrograms/ml were obtained. These values are similar to reported values in previous studies using GM intramuscular injection. 2. High urinary concentrations were observed up to 6 hours after administration, and the urinary recovery rate was approximately 60%. 3. Of a total of 142 cases collected, 117 cases were evaluated. Efficacy rates by diseases were: 100% in pneumonia (30/30), 98.3% in urinary tract infections (59/60), and 92.3% in other infections (skin and soft tissue) (12/13), with an overall efficacy rate of 94.9% (including 77 "excellent" cases). 4. Bacteriological examinations showed high eradication rates with the use of GM; i.e., 80% with Staphylococcus aureus (8/10), 60% with Pseudomonas aeruginosa (3/5), 100% with Haemophilus influenzae (7/7) and 97.8% with Escherichia coli (44/45), achieving an overall eradication rate of 92.4%. In mixed infections, the eradication rate was 85.7% (6/7). 5. No ototoxicity, nephrotoxicity or allergic reactions was observed. Abnormal laboratory findings observed were: GOT elevation in 3.1% of cases, GPT elevation in 3.9%, platelet increase in 1.5% and eosinophil increase in 0.8%, thus an overall rate of the appearance of abnormality was 5.6%. The above results indicate that an intravenous drip infusion of GM is a useful method for treating infections in pediatrics.
庆大霉素儿科研究小组对静脉滴注庆大霉素（GM）进行了一项多诊所研究。结果总结如下：1. 以2.0 - 2.5毫克/千克的剂量在0.5 - 1小时内静脉滴注GM时，可获得4 - 12微克/毫升的治疗有效血清浓度。这些值与先前使用GM肌肉注射的研究报告值相似。2. 给药后6小时内观察到高尿浓度，尿回收率约为60%。3. 在总共收集的142例病例中，评估了117例。各疾病的有效率分别为：肺炎100%（30/30），尿路感染98.3%（59/60），其他感染（皮肤和软组织）92.3%（12/13），总体有效率为94.9%（包括77例“优秀”病例）。4. 细菌学检查显示使用GM时根除率较高；即金黄色葡萄球菌为80%（8/10），铜绿假单胞菌为60%（3/5），流感嗜血杆菌为100%（7/7），大肠杆菌为97.8%（44/45），总体根除率为92.4%。在混合感染中，根除率为85.7%（6/7）。5. 未观察到耳毒性、肾毒性或过敏反应。观察到的实验室异常结果为：3.1%的病例谷草转氨酶升高，3.9%的病例谷丙转氨酶升高，1.5%的病例血小板增多，0.8%的病例嗜酸性粒细胞增多，因此异常出现的总体发生率为5.6%。上述结果表明，静脉滴注GM是治疗儿科感染的一种有用方法。
