Sakata H, Ishida C, Kakehashi H, Fujita K, Yoshioka H, Mori Y, Maruyama S, Sakata Y, Takimoto M
Department of Pediatrics, Asahikawa Medical College.
Jpn J Antibiot. 1988 May;41(5):549-56.
Eighteen children with urinary tract infection were treated with intravenous drip infusion of gentamicin (GM), and clinical efficacy and pharmacokinetics were studied. Ages of the patients ranged from 2 months to 12 years. Doses of GM ranged 1.0 to 2.5 mg/kg every 8 to 12 hours, and treatment continued for 4 to 10 days. Among 18 patients treated, clinical results were excellent in 12, and good in 6. Values of BUN and creatinine remained within normal range in all patients during and after the GM treatment. One child had an eosinophilia. There were no cases that showed signs and symptoms of oto- and nephrotoxicity. Twenty eight time-serum level curves were studied in 16 patients during and after intravenous infusion of GM over 30 minutes. Doses were 1.0 mg/kg in 4, 1.9-2.0 mg/kg in 14, and 2.2-2.5 mg/kg in 10. Peak serum levels at 30 minutes after the start of infusion were 2.66-7.38 micrograms/ml (average 5.45 micrograms/ml) in cases receiving 1.0 mg/kg, 4.67-10.8 micrograms/ml (7.26 micrograms/ml) in 1.9-2.0 mg/kg, and 6.16-16.5 micrograms/ml (8.86 micrograms/ml) in 2.2-2.5 mg/kg. Elimination half-lives were 1.75-2.48 hours (average 2.10 hours) in cases with ages less than 1 year, 1.58-2.58 hours (2.01 hours) with 1 to 6 years, and 1.20-3.07 hours (1.66 hours) with 7 to 12 years who were given doses of 1.9-2.5 mg/kg. There were no significant differences in pharmacokinetic parameters between first and last administration in these patients, suggesting that no accumulation occurred with above mentioned doses. Urinary recovery of GM ranged from 21.9 to 99.2 percent (average 62.48%) within 6.5 hours after the initiation of drip infusion.
18例尿路感染患儿接受庆大霉素（GM）静脉滴注治疗，并对其临床疗效和药代动力学进行了研究。患者年龄从2个月至12岁不等。GM剂量为每8至12小时1.0至2.5mg/kg，治疗持续4至10天。在接受治疗的18例患者中，12例临床结果为优，6例为良。在GM治疗期间及之后，所有患者的尿素氮和肌酐值均保持在正常范围内。1例患儿出现嗜酸性粒细胞增多。未出现表现出耳毒性和肾毒性体征及症状的病例。在16例患者静脉滴注GM超过30分钟期间及之后，研究了28条时间-血清水平曲线。剂量为4例1.0mg/kg、14例1.9 - 2.0mg/kg、10例2.2 - 2.5mg/kg。输注开始后30分钟时，接受1.0mg/kg剂量的患者血清峰值水平为2.66 - 7.38μg/ml（平均5.45μg/ml），1.9 - 2.0mg/kg剂量的患者为4.67 - 10.8μg/ml（7.26μg/ml），2.2 - 2.5mg/kg剂量的患者为6.16 - 16.5μg/ml（8.86μg/ml）。年龄小于1岁的患者给予1.9 - 2.5mg/kg剂量时，消除半衰期为1.75 - 2.48小时（平均2.10小时）；1至6岁患者为1.58 - 2.58小时（2.01小时）；7至12岁患者为1.20 - 3.07小时（1.66小时）。这些患者首次给药和末次给药的药代动力学参数无显著差异，表明上述剂量未出现蓄积。GM静脉滴注开始后6.5小时内，尿回收率为21.9%至99.2%（平均62.48%）。
