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结核分枝杆菌代谢酶兼职抗炎效应蛋白。

An M. tuberculosis Metabolic Enzyme Moonlights as an Anti-Inflammatory Effector Protein.

机构信息

Department of Internal Medicine, Division of Infectious Diseases, UC Davis Health, Sacramento, CA, USA; Department of Medical Microbiology and Immunology, University of California, Davis, Davis, CA, USA.

Department of Internal Medicine, Division of Infectious Diseases, UC Davis Health, Sacramento, CA, USA; Department of Medical Microbiology and Immunology, University of California, Davis, Davis, CA, USA.

出版信息

Cell Host Microbe. 2020 Mar 11;27(3):310-312. doi: 10.1016/j.chom.2020.02.012.

DOI:10.1016/j.chom.2020.02.012
PMID:32164839
Abstract

The mechanisms by which Mycobacterium tuberculosis evades host immunity remain enigmatic. In a recent study in the journal Nature, Wang et al. report that an enzyme acting in the bacterial cytoplasm to degrade lipids also acts as an effector protein in the host cell cytoplasm to suppress inflammation.

摘要

结核分枝杆菌逃避宿主免疫的机制仍然是个谜。在最近发表在《自然》杂志上的一项研究中,Wang 等人报告说,一种在细菌细胞质中降解脂质的酶也作为效应蛋白在宿主细胞质中发挥作用,抑制炎症。

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