感受燃烧：肠上皮细胞响应细菌发酵产物改变其脂代谢。

Feeling the Burn: Intestinal Epithelial Cells Modify Their Lipid Metabolism in Response to Bacterial Fermentation Products.

机构信息

Department of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine, Durham, NC 27710, USA.

出版信息

Cell Host Microbe. 2020 Mar 11;27(3):314-316. doi: 10.1016/j.chom.2020.02.009.

DOI:10.1016/j.chom.2020.02.009

PMID:32164841

Abstract

Intestinal epithelial absorption of dietary lipids is a major determinant of animal energy balance and metabolic health. Recent studies uncovered significant roles for intestinal microbiota in this process, but underlying mechanisms remain unresolved. Araújo et al. (2020) identify two end-products of bacterial fermentation that regulate intestinal lipid absorption and metabolism.

摘要

肠道上皮细胞对膳食脂质的吸收是动物能量平衡和代谢健康的主要决定因素。最近的研究揭示了肠道微生物群在这一过程中的重要作用，但潜在的机制仍未解决。Araújo 等人（2020 年）确定了两种细菌发酵的终产物，它们调节肠道脂质的吸收和代谢。