R.K. Mellon Institute for Pediatric Research, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA.
Cell Host Microbe. 2020 Mar 11;27(3):319-321. doi: 10.1016/j.chom.2020.02.011.
The microbiota is necessary for the induction of intestinal immunoglobulin A (IgA). In this issue of Cell Host & Microbe, Yang et al. (2020) show that the ability to induce or suppress IgA is characteristic of specific strains of Bacteroides ovatus. Immunogenicity and IgA induction by the microbiota is determined by inter-bacterial interaction.
肠道微生物菌群对于诱导肠道免疫球蛋白 A(IgA)是必需的。在本期《细胞宿主与微生物》杂志中,Yang 等人(2020)表明,诱导或抑制 IgA 的能力是特定卵形拟杆菌菌株的特征。菌群的免疫原性和 IgA 诱导作用由细菌间的相互作用决定。